Smad核相互作用蛋白1抗体说明书 英文名称  Anti-SNIP1

中文名称  Smad核相互作用蛋白1抗体说明书 

别    名 FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein (Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75).

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep

产品类型   一抗  

研究领域    信号转导 生长因子和激素 表观遗传学

蛋白分子量  predicted molecular weight: 46kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SNIP1

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Smad核相互作用蛋白1抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle.

Function : Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis.

Subunit : Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN.

Subcellular Location : Nucleus.

Tissue Specificity : Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle.

Post-translational modifications : Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.

DISEASE : Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]. A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period.

Similarity : Contains 1 FHA domain.

Database links : UniProtKB/Swiss-Prot: Q8TAD8.1

实验流程：

全、新、优、品、好四大特点：

Smad核相互作用蛋白1抗体说明书 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

高盐度脑心浸液肉汤2ml*20支用于细菌增菌培养

溴棕铵琼脂 选择分离和鉴别铜绿假单胞菌 500g incubation media 溴棕铵琼脂 选择分离和鉴别铜绿假单胞菌 500g

串珠镰孢 油漆腐蚀菌 支/瓶

品红亚琼脂(即用型)/瓶用于饮用水，水源水中总大肠菌群的选择性分离和确证

GetrimideAgarMedium

哥伦比亚培养基250g用于多种微生物的增菌培养

亚铋琼脂(BS) Bismuth Sulfite Agar 用于沙门氏菌的选择性分离(GB、SN标准)

肝浸粉 Liver Infusion 100 培养基原材料，为营养要求高的细菌提供生长营养成份

布氏肉汤250g/瓶用于弯曲菌分离及动力试验incubationmedia布氏肉汤250g/瓶用于弯曲菌分离及动力试验

Endo培养基 250g 用于大肠菌群的确诊试验(APHA)

MH琼脂(MHA)250g用于抗生素敏感试验

MERCK默克 incubation media 　 　 MERCK默克

甘露醇卵黄多粘菌素琼脂基础MYP 250g 用于蜡样芽孢杆菌的菌数测定及分离培养(GB/T4789.28-2003中4.64，GB/T4789.14-2003，SN0176-92和...

骨髓间质干细胞成骨诱导分化培养基Adultbonemarrowmesenchymalstemcells,osteogenicdifferentiationmedium

EsculinMedium

CL-0226SW626(人细胞)5×106cells/瓶×2

FAM19A4 Others Human 人 FAM19A4 / TAFA4 人细胞裂解液 (阳性对照)

人牙龈成纤维细胞cDNAHGF cDNA

猪胚胎传代细胞;ST 子细胞，SiHa细胞 B22细胞，KM小鼠未分化神经瘤株

Sars结构蛋白表达株;293sars181A

HA Others H5N1 甲型 H5N1 血凝素HA1 (Hemagglutinin) 人细胞裂解液 (阳性对照)

Smad核相互作用蛋白1抗体说明书CL-0224SW579(人甲状腺鳞癌细胞 )5×106cells/瓶×2

PARP1 Others Human 人 PARP-1 / PARP 杆状病毒-昆虫细胞裂解液 (阳性对照)

人淋巴成纤维细胞cDNAHLF cDNA

F9细胞， 人肺泡上皮细胞,HPAEpiC细胞 肝实质细胞Many types of cells包装：5 ×105次方(1ml)

狗肾细胞;Super Tube

THPO Others Mouse 小鼠 Thrombopoietin / THPO / TPO 人细胞裂解液 (阳性对照)

技术外包服务:

★Smad核相互作用蛋白1抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。