丝氨酸蛋白酶抑制剂B11抗体说明书 英文名称  Anti-SERPINB11

中文名称  丝氨酸蛋白酶抑制剂B11抗体说明书 

别    名 EPIPIN; Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 11 antibody Serpin B11 antibody Serpin peptidase inhibitor clade B (ovalbumin) member 11 antibody SERPINB11d antibody SERPINB11e antibody SERPINB11f; SPB11_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human

产品类型   一抗  

研究领域    细胞生物 激酶和磷酸酶

蛋白分子量  predicted molecular weight: 44kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SERPINB11

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

丝氨酸蛋白酶抑制剂B11抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. SerpinB11 (serpin peptidase inhibitor, clade B (ovalbumin), member 11), also known as EPIPIN or SERPIN11, is a 392 amino acid cytoplasmic protein that belongs to the Ov-serpin subfamily and serpin family. Like other members of the serpin family, SerpinB11 has been identified as a noninhibitory intracellular protein. The gene encoding SerpinB11 maps to human chromosome 18, which houses over 300 protein-coding genes and contains nearly 76 million bases. There are a variety of diseases associated with defects in chromosome 18-localized genes, some of which include Trisomy 18 (also known as Edwards syndrome), Niemann-Pick disease, hereditary hemorrhagic telangiectasia, erythropoietic protoporphyria and follicular lymphomas.

Function : Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.

Subcellular Location : Cytoplasmic

Tissue Specificity : Detected in a restricted number of tissues, including lung, placenta, prostate, and tonsil.

Similarity : Belongs to the serpin family. Ov-serpin subfamily.

Database links : UniProtKB/Swiss-Prot: Q96P15.1

实验流程：

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