中文名称  染色体特异性转录延伸因子抗体规格 

英文名称  Anti-SUPT16H/CDC68

别    名 CDC68; Chromatin specific transcription elongation factor 140 kDa subunit; Chromatin-specific transcription elongation factor 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT; FACT complex subunit SPT16; FACTP140; FLJ10857; FLJ14010; hSPT16; SP16H_HUMAN; Suppressor of Ty 16 homolog; Supt16h.

产品属性：

染色体特异性转录延伸因子抗体规格 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish

产品类型   一抗  

研究领域    细胞生物 信号转导 细胞周期蛋白 转录调节因子 细胞分化 表观遗传学

蛋白分子量  predicted molecular weight: 120kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SUPT16H/CDC68

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

染色体特异性转录延伸因子抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Function : Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). Also involved in vitamin D-coupledtranscription regulation via its association with the WINACcomplex, a chromatin-remodeling complex recruited by vitamin Dreceptor (VDR), which is required for the ligand-bound VDR-mediatedtransrepression of the CYP27B1 gene (By similarity).

Subunit : Component of the FACT complex, a stable heterodimer ofSSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complexwhich forms following UV irradiation, composed of SSRP1, SUPT16H,CSNK2A1, CSNK2A2 and CSNK2B. Component of the WINAC complex, atleast composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2,SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A andTOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interactswith GTF2E2.

Subcellular Location : Nucleus. Chromosome. Note=Colocalizes withRNA polymerase II on chromatin. Recruited to actively transcribedloci.

Tissue Specificity : Ubiquitous.

Post-translational modifications : ADP-ribosylated. ADP-ribosylation by PARP1 is induced bygenotoxic stress and correlates with dissociation of FACT fromchromatin.

Similarity : Belongs to the peptidase M24 family. SPT16 subfamily.

Database links : UniProtKB/Swiss-Prot: Q9Y5B9.1

实验流程：

全、新、优、品、好四大特点：

染色体特异性转录延伸因子抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★染色体特异性转录延伸因子抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

锌指蛋白281 多克隆抗体  ZN281 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

锌指蛋白335 多克隆抗体  ZN335 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

锌指蛋白366 多克隆抗体  ZN366 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

锌指蛋白416 多克隆抗体  ZN416 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

锌指蛋白440 多克隆抗体  ZN440 Polyclonal Antibody  700/30ul#1540/100ul#2520/200ul

磷酸化Bax抗体     原癌基因CBL2抗体

磷酸化抗雌激素耐药蛋白1抗体     原癌基因c FGR抗体

磷酸化Bcl-2抗体     原癌基因Bcl-6抗体

磷酸化Bcl-xL蛋白抗体     原癌基因AF4蛋白抗体

神经母细胞瘤相关蛋白ARID3B抗体     原癌蛋白CBL2抗体

锌指蛋白274抗体     2号染色体开放阅读框55抗体

锌指蛋白81抗体     2号染色体开放阅读框54抗体

锌指蛋白148抗体     2号染色体开放阅读框53抗体

锌指蛋白342抗体     2号染色体开放阅读框50抗体

锌指蛋白350/易感基因1结合蛋白抗体     2号染色体开放阅读框49抗体

虎杖 Polygonum cuspidatum Sieb. et Zucc. Resveraol 白藜芦醇 501-36-0 C14H12O3 ≥98%

断血流皂苷AClinopodiumscponincHPLC≥98%,20mg/支

DL-薄荷醇 DL-Menthol 15356-70-4 20mg HPLC≥98% 用于含量测定

中药对照药材菝葜(金刚藤)121466-200401TLC法鉴别

Nepetin泽兰黄酮纯度：>98%

染色体特异性转录延伸因子抗体规格格列喹酮 Gliquidone 分 子 量：527.6300 CAS编号：33342-05-1 分子式：C27H33N3O6S 别　　名：糖肾平;美普他酚盐酸盐 基本用途：含量测定。

远志Polygala tenuifolia Willd. Polygalaxanthone III 远志三同III 162857-78-5 C25H28O15 石油溴价测定用标准物质060121

中药对照药材黑豆120975-200203TLC法鉴别

75mg

滇五味子Schisandra heyi var. yunnanensis Kadsuric acid 南五味子酸 62393-88-8 C30H46O4 ≥95%