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5-羟色胺受体3D+3E抗体规格 英文名称  Anti-5HT3D + 5HT3E Receptor

中文名称  5-羟色胺受体3D+3E抗体规格 

别    名 5 HT3 D; 5 HT3 E; 5 HT3c1; 5 HT3D; 5 HT3E; 5 hydroxytryptamine (serotonin) receptor 3 family member D; 5 hydroxytryptamine (serotonin) receptor 3 family member E; 5 hydroxytryptamine receptor 3 subunit D; 5 hydroxytryptamine receptor 3 subunit E; 5 hydroxytryptamine receptor 3D; 5 hydroxytryptamine receptor 3E; 5HT3D; HTR3D; HTR3E; MGC119636; MGC119637; MGC120035; MGC120036; MGC120037; Serotonin 5 HT 3D receptor; Serotonin receptor 3D; Serotonin receptor 3E; 5HT3D_HUMAN; 5HT3E_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human

产品类型   一抗  

研究领域    神经生物学 细胞膜受体 G蛋白偶联受体 G蛋白信号

蛋白分子量  predicted molecular weight: 48kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human 5HT3D + 5HT3E Receptor

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

5-羟色胺受体3D+3E抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Serotonin is a monoamine neurotransmitter that is made in serotonergic neurons in the CNS (central nervous system) and is important in the regulation of mood, sleep, vomiting, sexuality and appetite. 5-HT3 (5-hydroxytryptamine-3) receptor is the only ligand-gated ion channel within the family of serotonin receptors. It is composed of five subunits consisting of SR-3A, SR-3B, HTR3C, HTR3D and HTR3E. HTR3D (5-hydroxytryptamine receptor 3D), also known as Serotonin receptor 3D, is a 454 amino acid multi-pass membrane protein that is one components of the pentaheteromeric complex that forms the 5-HT3 receptor. HTR3D must be co-expressed with SR-3A to form a functional 5-HT3 receptor complex on the plasma membrane. Until it is complexed with SR-3A, HTR3D is localized within the endoplasmic reticulum. Expression of HTR3D is restricted to kidney, colon and liver. There are three different isoforms of HTR3D that are expressed as a result of alternative splicing events.

Function : 5HT3D Receptor and 5HT3E Receptor are receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The receptors form a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Subunit : Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

Subcellular Location : Cell membrane; Multi-pass membrane protein. Note: Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Tissue Specificity : Expressed in liver, as well as fetal and adult colon and kidney.

Similarity : Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3D sub-subfamily.

Database links : UniProtKB/Swiss-Prot: Q70Z44.3 UniProtKB/Swiss-Prot: A5X5Y0.1

实验流程：

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