钠通道蛋白10α抗体规格 英文名称  Anti-SCN10A/NAV1.8

中文名称  钠通道蛋白10α抗体规格 

别    名 mPN3; Peripheral nerve sodium channel 3; Pn3 (gene name)v PN3; Scn10a; Sensory neuron sodium channel; Sns (gene name); SNS; sodium channel protein type 10 subunit alpha; Sodium channel protein type X alpha subunit; Voltage-gated sodium channel alpha subunit Nav1.8.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow

产品类型   一抗  

研究领域    神经生物学 通道蛋白 细胞膜受体

蛋白分子量  predicted molecular weight: 215kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SCN10A/NAV1.8

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

钠通道蛋白10α抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Nav1.8 protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, Nav1.8 forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Nav1.8 plays a role in neuropathic pain mechanisms.

Function : This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.

Subunit : The voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.

Subcellular Location : Membrane; Multi-pass membrane protein. Note=It can be translocated to the extracellular membrane through association with S100A10.

Tissue Specificity : Expressed in the dorsal root ganglia and sciatic nerve.

Post-translational modifications : Ubiquitinated by NEDD4L; which promotes its endocytosis.

Similarity : Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.

Contains 1 IQ domain.

实验流程：

全、新、优、品、好四大特点：

钠通道蛋白10α抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

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葡萄 Vitis vinifera L. Procyanidin B1 原花青素B1 20315-25-7 C30H26O12 ≥98%

紫菀同Shiononq20mg/支

突厥烯同;大马同 Damascenone 23696-85-7 20mg HPLC≥98% 突厥烯同 23696-85-7

中药对照药材箭根薯121400-200401TLC法鉴别

Aglycone - F11人参苷元F11纯度：≥97%

钠通道蛋白10α抗体规格五味子醇乙 Schisandrol B (≥98%,HPLC) 58546-54-6 20MG 标准品

云南铁杉Tsuga dumosa 石耳酸 548-89-0 C24H20O10 ≥98% 甘草酸铵(G0460000

对照品大蒜素100384-200401UV法含量测定

D标准品50mg标准品

猪脑和蛋黄pig grain and yolk Cholesterol 胆固醇 57-88-5 C27H46O ≥98%

技术外包服务:

★钠通道蛋白10α抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。