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SMAD家族9抗体规格
  • 品牌:上海莼试
  • 产地:进口、国产
  • 货号:CS12162
  • 发布日期: 2019-02-18
  • 更新日期: 2024-11-22
产品详请
产地 进口、国产
品牌 上海莼试
保存条件 Store at -20 °C
货号 CS12162
应用范围 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
CAS编号
抗体名 Anti-SMAD9
克隆性
靶点 详见说明书
适应物种 详见说明书
形态 详见说明书
宿主 详见说明书
亚型 IgG
标识物 详见说明书
浓度 1mg/1ml%
免疫原 KLH conjugated synthetic peptide derived from human SMAD9

中文名称  SMAD家族9抗体规格 

英文名称  Anti-SMAD9

     MAD homolog 9; MADH6; Mothers against decapentaplegic; Mothers against decapentaplegic homolog 9; SMAD 9; SMAD family member 9; SMAD, mothers against DPP homolog 9 (Drosophila); SMAD8A; SMAD8B; Smad9.

产品属性:

SMAD家族9抗体规格       1mg/1ml

  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse

产品类型   一抗  

研究领域     免疫学 染色质和核信号 信号转导 干细胞 生长因子和激素 转录调节因子

蛋白分子量  predicted molecular weight: 52kDa 

       Lyophilized or Liquid

  KLH conjugated synthetic peptide derived from human SMAD9

      IgG

纯化方法   affinity purified by Protein A

   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

SMAD家族9抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

(石蜡切片需做抗原修复) 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 SMAD9 is a member of the MAD-related family of molecules. MAD-related proteins are a recently identified family of intracellular proteins that are thought to be essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily.

Function : Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Subunit : Interaction with the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit.

Subcellular Location : Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).

Tissue Specificity : Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

Post-translational modifications : Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.

DISEASE : Defects in SMAD9 may be a cause of primary pulmonary hypertension (PPH1) [MIM:178600]. A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Similarity : Belongs to the dwarfin/SMAD family.

Contains 1 MH1 (MAD homology 1) domain.

Contains 1 MH2 (MAD homology 2) domain.

实验流程:

全、新、优、品、好四大特点:

SMAD家族9抗体规格 全:公司提供上万种产品,涵盖了生物试剂,elisa试剂盒,标准品,培养基,原装耗材,抗体、培养基、ATCC细胞等,基本上各种科研所需产品在我司都能找到。

新:产品更新速度较快,基本上每周都有新产品出现。

优:产品质量好,投诉比较少。

好:我公司具有优质的技术团队,产品一旦售出,实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

SMAD家族9抗体规格 分子生物学:质粒抽提、PCRQ-PCRRT-PCR、分子生物学:基因合成、引物合成、基因测序、载体构建等

蛋白工程:原核、哺乳动物蛋白表达系统等

病毒包装:腺病毒、慢病毒等

抗体工程:磁珠分选、病理染色、WBELISAIPIFIHCFACSConfocal等等

细胞工程:细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

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