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磷酸化神经突触前膜胞内蛋白抗体品牌 英文名称  Anti-phospho-STXBP1(Ser515)

中文名称  磷酸化神经突触前膜胞内蛋白抗体品牌 

别    名 Stxbp1(phospho S515); FLJ37475; hUNC 18; hUNC18; Munc 18 1; Munc 18; Munc 18a; Munc18 1; Munc18a; N Sec1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STX BP1; STXB1_HUMAN; STXBP 1; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 1; UNC 18; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18 homolog; Unc18-1; Unc18A.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗 磷酸化抗体  

研究领域     细胞生物 免疫学 神经生物学 结合蛋白

蛋白分子量  predicted molecular weight: 68kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human STXBP1 around the phosphorylation site of Ser515

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

磷酸化神经突触前膜胞内蛋白抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Munc18 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Munc18 can interact with syntaxins 1, 2, and 3 but not syntaxin 4. It may play a role in determining the specificity of intracellular fusion reactions. Mutations in Munc18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Two Munc18 isoforms have recently been identified. Munc18-1 has been shown to be primarily expressed in brain, while Munc18-2 is expressed in most tissues.

Function : May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.

Subunit : Binds SYTL4 (By similarity). Interacts with STX1A.

Subcellular Location : Cytoplasm. Membrane; Peripheral membrane protein.

Tissue Specificity : Brain and spinal cord. Highly enriched in axons.

DISEASE : Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.

Similarity : Belongs to the STXBP/unc-18/SEC1 family.

Database links : UniProtKB/Swiss-Prot: P61764.1

实验流程：

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