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神经突起生长诱导因子受体Unc5a抗体费用 英文名称  Anti-Unc5a/UNC5H1

中文名称  神经突起生长诱导因子受体Unc5a抗体费用 

别    名 Netrin receptor UNC 5A; Netrin receptor UNC5A; Netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; Unc 5 homolog 1; Unc 5 homolog A; Unc 5a; Unc5 a; Unc5 homolog 1; Unc5 homolog A; Unc5a; UNC5A_HUMAN; Unc5h1; FLJ16449; KIAA1976.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep

产品类型   一抗  

研究领域     细胞生物 神经生物学 转录调节因子

蛋白分子量  predicted molecular weight: 90kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Unc5a

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

神经突起生长诱导因子受体Unc5a抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Function : Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Subunit : Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC

Subcellular Location : Cell membrane. The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.

Post-translational modifications : Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

Similarity : Belongs to the unc-5 family.

Contains 1 death domain.

Contains 1 Ig-like (immunoglobulin-like) domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 TSP type-1 domain.

Contains 1 ZU5 domain.

Database links : UniProtKB/Swiss-Prot: Q6ZN44.3

实验流程：

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