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素A2受体抗体说明书
  • 品牌:上海莼试
  • 产地:进口、国产
  • 货号:CS11940
  • 发布日期: 2019-01-25
  • 更新日期: 2024-11-22
产品详请
产地 进口、国产
品牌 上海莼试
保存条件 Store at -20 °C
货号 CS11940
应用范围 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
CAS编号
抗体名 Anti-TXA2R
克隆性
靶点 详见说明书
适应物种 详见说明书
形态 详见说明书
宿主 详见说明书
亚型 IgG
标识物 详见说明书
浓度 1mg/1ml%
免疫原 KLH conjugated synthetic peptide derived from human Thromboxane A2 receptor

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素A2受体抗体说明书 英文名称  Anti-TXA2R

中文名称  素A2受体抗体说明书 

     Thromboxane A2 receptor; Prostanoid TP receptor; TBXA2R; TP receptor; TXA2 R; TXA2R.

产品属性:

      1mg/1ml

  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域    心 细胞生物 信号转导 细胞膜受体 G蛋白偶联受体

蛋白分子量  predicted molecular weight: 40-55kDa 

       Lyophilized or Liquid

  KLH conjugated synthetic peptide derived from human Thromboxane A2 receptor

      IgG

纯化方法   affinity purified by Protein A

   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

素A2受体抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

(石蜡切片需做抗原修复) 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Thromboxane A2 receptor is a member of the G protein-coupled receptor superfamily. It performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. Thromboxane A2 is an arachidonic acid metabolite produced by the action of thromboxane synthase on prostaglandin endoperoxide H(2) (PGH(2)), which results from the enzymatic transformation of arachidonic acid by the cyclooxygenases (COX-1 and COX-2). In humans Thromboxane A2 signals through two distinct Thromboxane A2 receptor isoforms which differ only in their C-terminal tails: alpha form (placenta) and beta form (endothelium). The interaction between Thromboxane A2 receptor and Thromboxane A2 is involved in the pathogenesis of numerous cardiovascular diseases such as atherosclerosis. Consequently, designing Thromboxane A2 receptor antagonists remains of great interest in cardiovascular medicine.

Function : Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Subunit : Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with GNB2L1/RACK1; the interaction regulates TBXA2R cell surface expression.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Similarity : Belongs to the G-protein coupled receptor 1 family.

实验流程:

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