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髓系细胞触发受体2抗体品牌
  • 品牌:上海莼试
  • 产地:进口、国产
  • 货号:CS11935
  • 发布日期: 2019-01-25
  • 更新日期: 2024-11-22
产品详请
产地 进口、国产
品牌 上海莼试
保存条件 Store at -20 °C
货号 CS11935
应用范围 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
CAS编号
抗体名 Anti-TREM2
克隆性
靶点 详见说明书
适应物种 详见说明书
形态 详见说明书
宿主 详见说明书
亚型 IgG
标识物 详见说明书
浓度 1mg/1ml%
免疫原 KLH conjugated synthetic peptide derived from human TREM2

技术外包服务:

髓系细胞触发受体2抗体品牌 分子生物学:质粒抽提、PCRQ-PCRRT-PCR、分子生物学:基因合成、引物合成、基因测序、载体构建等

蛋白工程:原核、哺乳动物蛋白表达系统等

病毒包装:腺病毒、慢病毒等

抗体工程:磁珠分选、病理染色、WBELISAIPIFIHCFACSConfocal等等

细胞工程:细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

实验流程:

髓系细胞触发受体2抗体品牌 英文名称  Anti-TREM2

中文名称  髓系细胞触发受体2抗体品牌 

     TREM-2; TREM2a; TREM2b; TREM2c; Trggering receptor expressed on myeloid cells 2; Trggering receptor expressed on myeloid cells 2a; Triggering receptor expressed on monocytes 2; TREM2_HUMAN.

产品属性:

      1mg/1ml

  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse

产品类型   一抗  

研究领域    免疫学

蛋白分子量  predicted molecular weight: 23kDa 

       Lyophilized or Liquid

  KLH conjugated synthetic peptide derived from human TREM2

      IgG

纯化方法   affinity purified by Protein A

   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

髓系细胞触发受体2抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

(石蜡切片需做抗原修复) 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The protein encoded by this gene is a membrane protein that forms a receptor signaling complex with TYROBP. The encoded protein may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.

Function : May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Subunit : Interacts with TYROBP/DAP12 (By similarity).

Subcellular Location : Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).

Isoform 2: Secreted (Potential).

Isoform 3: Secreted (Potential).

Tissue Specificity : Expressed on macrophages and dendritic cells but not on granulocytes or monocytes. In the CNS strongest expression seen in the basal ganglia, corpus callosum, medulla oblongata and spinal cord.

DISEASE : Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]; also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns.

Similarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Database links :

UniProtKB/Swiss-Prot: Q9NZC2.1

Entrez Gene: 54209 Human

Entrez Gene: 83433 Mouse

Omim: 605086 Human

SwissProt: Q9NZC2 Human

SwissProt: Q99NH8 Mouse

Unigene: 435295 Human

Unigene: 261623 Mouse

TREM-2是近年来发现应的重要标记物,也是感染性疾病的预警指标,与的严重程度相关。

TREM2属于免疫球蛋白超家族TREM,表达于白细胞的细胞膜表面受体,TREM-选择性地表达于中性粒细胞和部分单核细胞,它介导的信号传导通路在的发生和级联放大中起重要作用。

全、新、优、品、好四大特点:

髓系细胞触发受体2抗体品牌 全:公司提供上万种产品,涵盖了生物试剂,elisa试剂盒,标准品,培养基,原装耗材,抗体、培养基、ATCC细胞等,基本上各种科研所需产品在我司都能找到。

新:产品更新速度较快,基本上每周都有新产品出现。

优:产品质量好,投诉比较少。

好:我公司具有优质的技术团队,产品一旦售出,实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

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