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Toll样受体6抗体费用 英文名称  Anti-TLR6/CD286

中文名称  Toll样受体6抗体费用 

别    名 CD286; CD286 antigen; TLR 6; Toll like receptor 6 precursor.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Pig, Horse

产品类型   一抗  

研究领域    细胞生物 细胞膜受体

蛋白分子量  predicted molecular weight: 84kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TLR6 C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Toll样受体6抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The Toll like receptor family in mammal comprises a family of transmembrane proteins characterised by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. These proteins recognize different microbial products during infection and serve as an important phylogenetically conserved mediator/link between the innate and adaptive immune responses. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLRs characterised so far activate the MyD88/interleukin 1 receptor associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1 10) have been described.

TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates proinflammatory cascades, but also can lead to apoptotic responses.

Subunit : Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains.

Subcellular Location : Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.

Tissue Specificity : Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Similarity : Belongs to the Toll-like receptor family.

Contains 12 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

实验流程：

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