中文名称  踝蛋白抗体品牌 

英文名称  Anti-Talin

别    名 TLN 1; ILWEQ; Talin 1; Talin; TLN; TLN1.

产品属性：

踝蛋白抗体品牌 浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit

产品类型   一抗  

研究领域    细胞生物 免疫学 转录调节因子 细胞粘附分子

蛋白分子量  predicted molecular weight: 280kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Talin

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

踝蛋白抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations.

Function : Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

Subunit : Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.

Subcellular Location : Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles.

Similarity : FERM domain.

Contains 1 I/LWEQ domain.

TALIN-踝蛋白。是重要的细胞骨架肌动蛋白结合蛋白，由两个270kDa的亚单位组成的反向平行的同源二聚体，与整合蛋白B尾部的结合诱导了整合蛋白胞外结构域构象的改变,起到了对整合蛋白的激活。

实验流程：

全、新、优、品、好四大特点：

踝蛋白抗体品牌 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★踝蛋白抗体品牌 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

CGRP (calcitonin gene related peptide, CGRP) 降钙素基因相关肽Multi-class antibodies规格： 0.5mg

Anti-CCR-2B 细胞表面趋化因子受体2B抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh PBOV1 和癌高表达蛋白抗体 规格 0.2ml

CD84 Kit Human 人 CD84 ELISA配对抗体 ELISA

TSSC3 英文名称： 抑制转移候选基因3抗体 0.2ml

CA125 英文名称： 抗原抗体 0.1ml

Anti-CCR-2B 细胞表面趋化因子受体2B抗体Multi-class antibodies规格： 0.2ml

VEGF-D ELISA Kit 大鼠内皮细胞生长因子DMulti-class antibodies规格： 48T

Anti-Apaf-1/FITC 荧光素标记凋亡蛋白活性因子-1抗体(N端)IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh FAM78A/C9orf59 9号染色体开放阅读框抗体 规格 0.2ml

bFGF(Human basic fibroblast growth factor) ELISA Kit 人碱性成纤维细胞生长因子 96T

MMP9 英文名称： 基质金属蛋白酶9抗体 0.1ml

ACOX2 英文名称： 过氧化物酶酰基辅酶A氧化酶2抗体 0.2ml

Anti-Apaf-1/FITC 荧光素标记凋亡蛋白活性因子-1抗体(N端)IgGMulti-class antibodies规格： 0.2ml

Anti-TFR/CD71/FITC 荧光素标记转铁蛋白受体抗体IgGMulti-class antibodies规格： 0.2ml

neurofasciu-155 神经束蛋白-155Multi-class antibodies规格： 0.5mg

细胞因子信号传导抑制蛋白1抗体 Anti-Socs 1 0.1ml

5HTR2C 英文名称： 5-羟色胺受体2C抗体 0.2ml

Ephrin A5 英文名称： 酪酸蛋白激酶A5受体抗体 0.1ml

Rhesus antibody Rh Phospho-MAPKAPK2(Thr334) 磷酸化原活化蛋白激酶活化的蛋白激酶2抗体 规格 0.1ml

neurofasciu-155 神经束蛋白-155Multi-class antibodies规格： 0.5mg

大鼠磷脂酶A2(PL-A2)ELISA试剂盒 ，英文名： PL-A2 ELISA Kit

人TATA盒结合蛋白/TBP相关因子(TAF)ELISA检测试剂盒HumaATAboxbindingprotein/TBP-associatedfactors,TAFELISAKit 96T/48T

蜥蜴孕激素/孕酮(PROG)免疫试剂盒 Lizard progesterone,PROG ELISA kit

CLIAKitforPIIINPELISAKit大鼠Ⅲ型前胶原肽规格：48T/96T

饲料三聚胺比色法定量检测试剂盒50次

ELISAKitIL-3人白介素3规格：48T/96T

大鼠补体5a(C5a)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人锰超氧化物歧化酶(SOD2)免疫试剂盒 Human Superoxide dismase [Mn], mitochondrial (SOD2) ELISA kit

MouseVitaminB6,VB6ELISAKit小鼠维生素B6(VB6)ELISA试剂盒规格：96T/48T

石蜡切片组织CASPASE-9蛋白表达NBT显色光学显微镜检测试剂盒10/20次

HumanProteinCarbonyl,PCELISA试剂盒人羰基化蛋白(PC)ELISA试剂盒规格：96T/48T

Humahyroidhormoneaoaibodies,THAAELISAKit人甲状腺非肽激素抗体(THAA)ELISA试剂盒规格：96T/48T

踝蛋白抗体品牌 大鼠蛋白激酶D1(PRKD1)ELISA试剂盒 ，英文名： PRKD1 ELISA Kit

Human NOD like receptor (NLR) ELISA Kit 人NOD样受体(NLR)ELISA试剂盒

Ratsolubleierleukin-2receptor,IL-2sRαELISAkit 大鼠白介素2可溶性受体α链(IL-2sRα/CD25)ELISA试剂盒 96T/48T 进口分装

CLIAKitforCyclin-D1(MouseCyclin-D1)ELISAKit小鼠细胞周期素D1规格：48T/96T

细胞色素P450亚酶CYP2D6(AMMC)活性荧光定量检测试剂盒20次

RatFibrinogenDegradationProduct,FDPELISAKit大鼠血纤蛋白原降解产物(FDP)ELISA试剂盒规格：96T/48T