产地 | 进口、国产 |
品牌 | 上海莼试 |
保存条件 | Store at -20 °C |
货号 | CS11892 |
应用范围 | WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
CAS编号 | |
抗体名 | Anti-phospho-TPH(Ser19) |
克隆性 | |
靶点 | 详见说明书 |
适应物种 | 详见说明书 |
形态 | 详见说明书 |
宿主 | 详见说明书 |
亚型 | IgG |
标识物 | 详见说明书 |
浓度 | 1mg/1ml% |
免疫原 | KLH conjugated Synthesised phosphopeptide derived from human TPH around the phosphorylation site of Ser19 |
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磷酸化色氨酸羟化酶抗体说明书 英文名称 Anti-phospho-TPH(Ser19)
中文名称 磷酸化色氨酸羟化酶抗体说明书
别 名 Tph1(phospho S19); MGC119994; TPH 1; TPH; TPH1; TPRH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan hydroxylase 1; Tryptophan 5-hydroxylase 1; TPH1_HUMAN.
产品属性:
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Rabbit
产品类型 一抗 磷酸化抗体
研究领域 免疫学 神经生物学 信号转导
蛋白分子量 predicted molecular weight: 49kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human TPH around the phosphorylation site of Ser19
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
磷酸化色氨酸羟化酶抗体说明书 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].
Subunit : Homotetramer (By similarity).
Tissue Specificity : Isoform 2 seems to be less widely expressed than isoform 1.
Similarity : Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.
Database links : UniProtKB/Swiss-Prot: P17752.4
色氨酸在脑中首先由色氨酸羟化酶(tryoptophan hydroxylase)催化生成5羟色氨酸(5hydroxytryptophan),再经脱羧酶作用生成5羟色胺,色氨酸羟化酶(TPH)是5-HT生物合成的限速酶,因此,色氨酸羟化酶的缺少可导致5-羟色胺的含量下降。色氨酸羟化酶主要在*内代谢。
实验流程:
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