全、新、优、品、好四大特点：

受体相关因子2抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

受体相关因子2抗体费用 英文名称  Anti- TRAF2

中文名称  受体相关因子2抗体费用 

别    名 E3 ubiquitin-protein ligase TRAF2; MGC:45012; OTTHUMP00000022625; OTTHUMP00000064745; TNF receptor associated factor 2; TNF receptor-associated factor 2; TNF receptor-associated protein; TRAF 2; TRAF2; TRAF2_HUMAN; TRAP 3; TRAP; TRAP3; Tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域     心 神经生物学 信号转导 细胞凋亡 生长因子和激素 激酶和磷酸酶 细胞膜受体

蛋白分子量  predicted molecular weight: 56kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TRAF2 C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

受体相关因子2抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The induction of the various cellular responses mediated by tumor necrosis factor is initiated by its interaction with the TNFR1 and TNFR2 cell surface receptors. TRAF2 interacts with the cytoplasmic domain of TNFR2. TRAF2 is a common signal transducer for TNFR2 and CD40 that mediates activation of NF kappa B.

Function : Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Subunit : Homotrimer, and heterotrimer with TRAF1 and TRAF3 (via TRAF domain). The domain containing the RING-type and the first TRAF-type zinc finger can also form homodimers (in vitro). Interacts with TNFRSF1B/TNFR2, TNFRSF4, TNFRSF5/CD40, CD27/TNFRSF7, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF16/NGFR, TNFRSF17/BCMA, TNFRSF18/AITR, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1 and IL15RA. Interacts with CDK9, CSK, MAP3K1, MAP3K5, MAP3K11, MAP3K14, MAP4K2, RIPK1, RIPK2, TNIK, TBK1, SPHK1, TRADD, TRAFD1, TRAIP, TANK/ITRAF, TNFAIP3, TDP2, MAVS/IPS1, TICAM1 and TRPC4AP. Interacts with CASP8AP2, NFATC2IP, PEG3 and HIVEP3. Interacts with BIRC2 and BIRC3 N-terminus; a single BIRC2 or BIRC3 molecule interacts with a heterotrimer formed by TRAF1 and TRAF2, or a TRAF2 homotrimer. Identified in a complex composed of TRAF2, TRAF3, BIRC2 and/or BIRC3. Interaction with BIRC2 and/or BIRC3 is essential for degradation of NFKBIA and activation of NF-kappa-B. Interacts with CYLD, USP48, IKKA and IKKB. Interacts (via 'Lys-63'-linked polyubiquitin chains) with TAB2 and TAB3 (By similarity). Interaction with TAOK3 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (By similarity). Interacts with CASP12 under resting conditions; this interaction is reduced in ER stress conditions. Interacts (via zinc fingers) with DAB2IP (via C-terminus PER domain); the interaction occurs in a TNF-alpha-dependent manner (By similarity). Interacts with ERN1; the interaction requires DAB2IP. Interacts with DAB2IP. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) (By similarity).

Subcellular Location : Cytoplasm.

Tissue Specificity : soform 1 and isoform 2 are expressed in spleen, adipose tissues, skeletal muscles, thymus, testis, heart, lung, brain. Isoform 2 is very weakly expressed in heart, lung and brain.

Post-translational modifications : Phosphorylated at several serine residues within the first 128 amino acid residues. Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A. Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination. Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B (By similarity).

Undergoes both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination. Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117. 'Lys-63'-linked polyubiquitination promotes TRAF2-mediated activation of NF-kappa-B. Can be polyubiquitinated at several Lys residues via 'Lys-48'-linked ubiquitin chains in response to TNF signaling, leading to proteasomal degradation. Autoubiquitinated, leading to its subsequent proteasomal degradation. Polyubiquitinated by BIRC2 and SIAH2, leading to its subsequent proteasomal degradation. Not ubiquitinated by BIRC3 or SIAH1. Deubiquitinated by CYLD, a protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (By similarity).

Similarity : Belongs to the TNF receptor-associated factor family. A subfamily.

Contains 1 MATH domain.

Contains 1 RING-type zinc finger.

Contains 2 TRAF-type zinc fingers.

Database links :

UniProtKB/Swiss-Prot: P39429.1

Entrez Gene: 7186 Human

Entrez Gene: 22030 Mouse

Entrez Gene: 311786 Rat

Omim: 601895 Human

SwissProt: Q12933 Human

SwissProt: P39429 Mouse

Unigene: 522506 Human

Unigene: 3399 Mouse

信号传导（Signaling Intermediates）

TRAF2在介导细胞凋亡信号及在细胞的凋亡中发挥着一定的作用。TRAF2分布较广泛，在所有检测的组织中都有表达，包括、脑、*、肺、肝、骨骼肌、肾和睾丸等，TRAF2可以介导TNFRII、CD40、CD30和EV转化蛋白LMP1活化NF-kB。

实验流程：

正在热销的相关产品：

Eotaxin human 人噬酸性粒细胞趋化因子Multi-class antibodies

Anti-phospho C-Myc(Thr58/pSer62) 磷酸化致癌基因C-Myc抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh NPD014 1号染色体开放阅读框63抗体 规格 0.1ml

FASL ELISA Kit 小鼠凋亡相关因子配体 96T

TRIB3 英文名称： 神经细胞死亡诱导蛋白激酶抗体 0.1ml

C6orf25 英文名称： 6号染色体开放阅读框25抗体 0.2ml

Anti-phospho C-Myc(Thr58/pSer62) 磷酸化致癌基因C-Myc抗体Multi-class antibodies规格： 0.1ml

PGF ELISA Kit 大鼠素FMulti-class antibodies规格： 48T

Anti-ASK1/MAPKKK5 /FITC 荧光素标记细胞凋亡信号调节激酶1/原活化蛋白激酶激酶激酶5抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh FAM120B 组织激活过氧化酶活化增生受体γ蛋白抗体 规格 0.2ml

IFI16/p16(Human interferon-inducible protein 16) ELISA Kit 人γ干扰素诱导蛋白16/p16 96T

MMP-7 英文名称： 基质金属蛋白酶-7抗体 0.1ml

ALDH1A2 英文名称： 乙醛脱氢酶2型抗体 0.1ml

Anti-ASK1/MAPKKK5 /FITC 荧光素标记细胞凋亡信号调节激酶1/原活化蛋白激酶激酶激酶5抗体IgGMulti-class antibodies规格： 0.2ml

Anti-TFPI/LACI /FITC 荧光素标记组织因子途径抑制剂抗体IgGMulti-class antibodies规格： 0.2ml

ASPP1(apoptosis stimulating protein of P53 1) p53凋亡刺激蛋白1抗原Multi-class antibodies规格： 0.5mg

蛋白抗体 Anti-Snake poison Protein 0.2ml

Synaptopodin 英文名称： 突触足蛋白抗体 0.1ml

ETS2 英文名称： 癌基因ETS2抗体 0.1ml

Rhesus antibody Rh phospho-MAPKAPK5(Thr182) 磷酸化p38调节/激活蛋白激酶抗体 规格 0.1ml

ASPP1(apoptosis stimulating protein of P53 1) p53凋亡刺激蛋白1抗原Multi-class antibodies规格： 0.5mg

大鼠黏着斑蛋白(VCL)ELISA试剂盒 ，英文名： VCL ELISA Kit

人P53(P53)ELISA检测试剂盒Humanp53/tumorprotein,p53/TP53ELISAKit 96T/48T

鱼雌二醇(E2)免疫试剂盒 Fish Esadiol,E2ELISA kit

CLIAKitforPCK(Humanphosphoenolpyruvatecarboxykinase)ELISAKit人磷酸烯醇式同酸羧激酶规格：48T/96T

树脂法微量全血DNA纯化试剂盒20次

ELISAKitC3人补体蛋白3规格：48T/96T

大鼠雌激素(E)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人免疫球蛋白M(IgM)免疫试剂盒 Human Immunoglobulin M,IgM ELISA Kit

MouseTumornecrosisfactorsolublereceptorⅡ,TNFsR-ⅡELISAKit小鼠坏死因子可溶性受体Ⅱ(TNFsR-Ⅱ)ELISA试剂盒规格：96T/48T

石蜡切片组织AKT蛋白表达NBT显色光学显微镜检测试剂盒10/20次

HumanProinsulin,PIELISA试剂盒人胰岛素原(PI)ELISA试剂盒规格：96T/48T

Humahrombomodulin，TMELISAKit人调节蛋白(TM)ELISA试剂盒规格：96T/48T

受体相关因子2抗体费用 大鼠二级淋巴组织趋化因子(SLC/CCL21)ELISA试剂盒 ，英文名： SLC/CCL21 ELISA Kit

Brain naiuretic peptide brain naiuretic peptide (BNP) ELISA Kit 猪脑素/脑尿肽(BNP)ELISA试剂盒

鹿特定基因序列(Deer)核酸检测试剂盒(PCR-荧光探针法) 48T

CLIAKitforM2-PKELISAKit大鼠同酸激酶M2型同工酶规格：48T/96T

体液总氨基酸含量荧光定量检测试剂盒20次

ELISAKitLPS鸡脂多糖/内毒素规格：48T/96T

技术外包服务:

★受体相关因子2抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。