中文名称  Toll样受体4抗体品牌 

英文名称  Anti-TLR4/CD284

别    名 TLR4; TLR-4; TLR 4; ARMD10; CD284; CD284 antigen; Homolog of Drosophila toll; hTol; Toll (Drosophila) homolog; TOLL; Toll Endotoxin Hyporesponsiveness; Toll like receptor 4; Toll like receptor 4 precursor; TLR4_HUMAN .

产品属性：

Toll样受体4抗体品牌 浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg 1ml/1mg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Sheep

产品类型   一抗  

研究领域    心 免疫学 信号转导 细胞膜受体

蛋白分子量  predicted molecular weight: 90kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TLR4

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Toll样受体4抗体品牌 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The Toll-like receptor 4 by activating natural immunity, specific immune response involved in the start-up, Toll-like receptor 4 as an important signal transduction transmembrane receptor involved in the toxin-induced inflammation in the pathological process, its mechanisms of control On a growing concern. all regions were either double-stranded or sequenced with an alternatechemistry or covered by high quality data(i.e., phred quality >=30); an attempt was made to resolve all sequencing problems, such as compressions and repeats; all regions were covered by at least one subclone; and the assembly was confirmed by restriction digest, except on the rare occasion of the clone being a YAC. The following abbreviations are used to associate primary accession numbers given in the feature table with their source databases: Em:, EMBL; Sw:, SWISSPROT; Tr:, TREMBL; Wp:, WORMPEP; Information on the WORMPEP database can be found at. TLR-4 plays an important role in microvascular leakage and leukocyte adhesion under the inflammatory condition associated with nonseptic thermal injury.

Function : Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.

Subcellular Location : Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.

Tissue Specificity : Membrane.

Post-translational modifications : N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.

DISEASE : Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

Similarity : Belongs to the Toll-like receptor family.

Contains 18 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 TIR domain.

Database links : UniProtKB/Swiss-Prot: O00206.2

Entrez Gene: 7099 Human

Entrez Gene: 21898 Mouse

Entrez Gene: 29260 Rat

SwissProt: O00206 Human

SwissProt: Q9QUK6 Mouse

SwissProt: Q9QX05 Rat

Unigene: 174312 Human

Unigene: 38049 Mouse

Toll样受体4（TLR4）通过激活天然免疫,参与特异性免疫应答的启动, Toll样受体4(TLR4)作为一种重要跨膜信号转导受体参与了内毒素诱发反应的病理过程,对其调控机制的研究日益受到关注.

实验流程：

全、新、优、品、好四大特点：

Toll样受体4抗体品牌 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★Toll样受体4抗体品牌 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

TGF Beta 1 人转化生长因子 β 1Multi-class antibodies

Anti-Claudin 1 紧密连接蛋白1抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh Nociceptin receptor 孤菲肽受体/痛敏肽受体抗体 规格 0.2ml

Human Beta amyloid precursor protein, BetaAPP ELISA Kit 人淀粉样前体蛋白 96T

Transferrin(1F10) 英文名称： 转铁蛋白单克隆抗体 0.1ml

C1orf114 英文名称： 1号染色体开放阅读框114抗体 0.2ml

Anti-Claudin 1 紧密连接蛋白1抗体Multi-class antibodies规格： 0.2ml

PAK7/PAK5/MBT 激活激酶PAK7/PAK5抗原Multi-class antibodies规格： 0.5mg

Anti-ATF2 活化复制因子2抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh phospho-APP/ABPP (Ser730) 磷酸化APP淀粉样肽前体蛋白抗体 规格 0.1ml

Somatostatin 生长抑素 浓缩液 0.1ml 进口分装

UBE2D4 英文名称： 泛素蛋白连接酶D4抗体 0.2ml

DDRGK1 英文名称： DDRGK1蛋白抗体 0.2ml

Anti-ATF2 活化复制因子2抗体Multi-class antibodies规格： 0.1ml

Anti-RECK/FITC 荧光素标记金属蛋白酶抑制因子RECK抗体IgGMulti-class antibodies规格： 0.2ml

5-HTR4(5 hydroxytryptamine serotonin receptor 4) 5-羟色胺受体4抗原Multi-class antibodies规格： 0.5mg

神经元素3抗体 anti-NGN3 0.2ml

Securin 英文名称： 垂体转化基因抗体 0.1ml

EXPB-2 英文名称： 植物延展素-β 1ml

Rhesus antibody Rh Phospho-p70 S6 Kinase Beta (Thr421/Ser424) 磷酸化核糖体S6蛋白激酶β2抗体 规格 0.1ml

5-HTR4(5 hydroxytryptamine serotonin receptor 4) 5-羟色胺受体4抗原Multi-class antibodies规格： 0.5mg

大鼠柠檬酸合酶(CS)ELISA试剂盒 ，英文名： CS ELISA Kit

人抗激素/加压素/精氨酸加压素(ADH/VP/AVP)ELISA检测试剂盒Humanaidiuretichormone/vasopressin/argininevasopressin,ADH/VP/AVPELISAKit 96T/48T

鱼骨钙素/骨谷氨酸蛋白(OT/BGP)免疫试剂盒 Fish Oste ocalcin/Bone gla protein,OT/BGP ELISA kit

CLIAKitforPDGF-AB(MousePlatelet-DerivedGrowthFactorAB)ELISAkit小鼠血小板衍生生长因子AB规格：48T/96T

噬菌体选择培养基I100毫升

ELISAKitC5b人补体片断5b规格：48T/96T

大鼠促肾上皮质激素释放激素(CRH)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

人性糖蛋白免疫试剂盒 Human Glycodelin ELISA Kit

MouseansformingGrowthfactorβ1,TGF-β1ELISAKit小鼠转化生长因子β1(TGF-β1)ELISA试剂盒规格：96T/48T

抗坏血酸待测样品处理试剂盒20次

HumanProcalcitonin,PCTELISA试剂盒人降钙素原(PCT)ELISA试剂盒规格：96T/48T

Humahioredoxieductase,xRELISAKit人硫氧还蛋白还原酶(xR)ELISA试剂盒规格：96T/48T

Toll样受体4抗体品牌 大鼠泛素羧基端酯酶L1(UCHL1)ELISA试剂盒 ，英文名： UCHL1 ELISA Kit

Rat iduronate sulfatase (IDS) ELISA Kit 大鼠艾杜糖酯酶(IDS)ELISA试剂盒

RatEotaxin1ELISAKit 大鼠嗜酸粒细胞趋化蛋白Eotaxin1(Eotaxin1/CCL11)ELISA试剂盒 96T/48T 进口分装

CLIAKitforD-LDHELISAKit大鼠D-乳酸脱氢酶规格：48T/96T

细胞人体鼻病毒(rhinovirus)定性检测试剂盒20次

Ratheatshockprotein20,hSP-20ELISAKit大鼠热休克蛋白20(HSP-20)ELISA试剂盒规格：96T/48T