金属蛋白酶组织抑制因子-2抗体说明书 英文名称  Anti-TIMP-2

中文名称  金属蛋白酶组织抑制因子-2抗体说明书 

别    名 Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep

产品类型   一抗  

研究领域     心 细胞生物 神经生物学 信号转导 细胞凋亡 生长因子和激素 合成与降解

蛋白分子量  predicted molecular weight: 24kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TIMP-2 (125-160aa)

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

金属蛋白酶组织抑制因子-2抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008].

Function : Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.

Subunit : Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.

Subcellular Location : Secreted.

Post-translational modifications : The activity of TIMP2 is dependent on the presence of disulfide bonds.

Similarity : Belongs to the protease inhibitor I35 (TIMP) family.

Contains 1 NTR domain.

Database links :

UniProtKB/Swiss-Prot: P16035.2

Entrez Gene: 282093 Cow

Entrez Gene: 100135629 Guinea pig

Entrez Gene: 7077 Human

Entrez Gene: 21858 Mouse

Entrez Gene: 100008689 Rabbit

Entrez Gene: 29543 Rat

Omim: 188825 Human

SwissProt: P16368 Cow

合成与降解（Synthesis and Degradation）

TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶，其功能与MMP相反，能细胞的浸润和转移，主要用于各种如等的研究。TIMP-2又称为CSC-21K，是一种21-24kDa的糖蛋白，在多种组织细胞中表达，它可以和MMPs家族成员以共价键方式形成复合物，从而发挥其。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。

实验流程：

全、新、优、品、好四大特点：

金属蛋白酶组织抑制因子-2抗体说明书 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

DISC1(disrupted in schizophrenia1)(CT) DISC1 C端抗原Multi-class antibodies规格： 0.5mg

Anti-CCR7/CD197 细胞表面趋化因子受体7抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh Paxillin 桩蛋白Paxillin抗体 规格 0.1ml

FCGR2B Kit Human 人 CD32b / FCGR2B ELISA配对抗体 ELISA

Transaldolase 1 英文名称： 转醛醇酶抗体 0.2ml

CSP 英文名称： 环子孢子蛋白(约氏)抗体 1ml

Anti-CCR7/CD197 细胞表面趋化因子受体7抗体Multi-class antibodies规格： 0.1ml

CT ELISA Kit 大鼠降钙素Multi-class antibodies规格： 48T

Anti-ATF3/FITC 荧光素标记活化转录因子3抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh FADD Fas死亡结构域相关蛋白 规格 0.1ml

CDT ELISA Kit 大鼠糖缺失性转铁蛋白 96T

1-Mar 英文名称： 膜相关环指蛋白1抗体 0.2ml

alpha 1 Fetoprotein 英文名称： 甲胎蛋白抗体 0.1ml

Anti-ATF3/FITC 荧光素标记活化转录因子3抗体IgGMulti-class antibodies规格： 0.2ml

Anti-VAMP-1/FITC 荧光素标记囊泡相关膜蛋白1抗体IgGMulti-class antibodies规格： 0.2ml

CD14(cluster of differentiation antigen 14) CD14/内毒素受体抗原Multi-class antibodies规格： 0.5mg

巨噬细胞炎性蛋白3α抗体 Anti-CCL20/MIP3αMacrophage inflammatory ptotein 3 alpha 0.1ml

SNAP23 英文名称： 突触相关蛋白23抗体 0.2ml

Exportin 5 英文名称： 核输出蛋白5抗体 0.2ml

Rhesus antibody Rh Phospho-HER4 (Tyr984) 磷酸化HER4抗体 规格 0.1ml

CD14(cluster of differentiation antigen 14) CD14/内毒素受体抗原Multi-class antibodies规格： 0.5mg

大鼠凝溶胶蛋白(Gelsolin)ELISA试剂盒 ，英文名： Gelsolin ELISA Kit

人抗α干扰素抗体(IFNα-Ab)ELISA检测试剂盒HumanIerferonαAibody,IFNα-AbELISAKit 96T/48T

鱼过氧化氢酶(CAT)免疫试剂盒 Fish Catalase,CAT ELISA kit

CLIAKitforPDGF-BB(HumanPlatelet-DerivedGrowthFactor-BB)ELISAkit人血小板衍生生长因子BB规格：48T/96T

噬菌体溶菌斑点杂交筛选试剂盒10次

ELISAKitADMA人不对称二甲基精氨酸规格：48T/96T

大鼠促肾上腺皮质激素(ACTH)ELISA试剂盒 ，英文名： ACTH ELISA Kit

Mouse 16 alpha hydroxy esone 1 (16- a OHE-1) ELISA Kit 小鼠16α羟基雌酮1(16-α OHE-1)ELISA试剂盒

ELISA 小鼠骨成型蛋白受体Ⅱ(mouse BMP-R2) 48T/96T 进口分装

CLIAKitforLIFRELISAKit大鼠抑制因子受体规格：48T/96T

通用型ECL免疫印迹化学发光溶液A液：50毫升B液：50毫升1000cm2

ELISAKit1,3-βDglucosidase鸡1,3-βD葡葡糖苷酶规格：48T/96T

金属蛋白酶组织抑制因子-2抗体说明书 大鼠芳香烃受体(AhR)ELISA试剂盒 ，英文名： AhR ELISA Kit

Orexin A (Orexin A) ELISA Kit 大鼠阿立新A(Orexin A)ELISA试剂盒

RatEndocrineglandvascularendothelialgrowthfactor,EG-VEGFELISAKit 大鼠腺来源的内皮生长因子(EG-VEGF)ELISA试剂盒 96T/48T 进口分装

CLIAKitforDNase-I(HumandeoxyribonucleaseI)ELISAKit人脱氧核糖核酸酶Ⅰ规格：48T/96T

细胞人类巨细胞病毒蛋白酶(HCMVPROTEASE)活性荧光淬灭法定量检测试剂盒20次

Ratheatshockprotein40,hSP-40ELISAKit大鼠热休克蛋白40(HSP-40)ELISA试剂盒规格：96T/48T

技术外包服务:

★金属蛋白酶组织抑制因子-2抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。