全、新、优、品、好四大特点：

tRNA剪接内切酶2抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

tRNA剪接内切酶2抗体费用 英文名称  Anti-TSEN2

中文名称  tRNA剪接内切酶2抗体费用 

别    名 HsSen2; MGC2776; MGC4440; SEN2; SEN2L; tRNA intron endonuclease Sen2; tRNA splicing endonuclease 2 homolog (SEN2, S. cerevisiae); tRNA splicing endonuclease subunit Sen2; TSEN 2; SEN2_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Cow, Horse, Sheep

产品类型   一抗  

研究领域    细胞生物 免疫学 细胞周期蛋白 细胞分化 表观遗传学

蛋白分子量  predicted molecular weight: 53kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TSEN2

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

tRNA剪接内切酶2抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The tRNA-splicing endonuclease complex is responsible for identifying and cleaving pre-tRNA at both 5’ and 3’ splice sites, thereby releasing introns and free tRNA molecules with 2',3' cyclic phosphates and 5'-OH termini. In addition to its role in pre-tRNA splicing, the heterotetrameric endonuclease complex participates in mRNA processing and, via its association with pre-mRNA processing factors, is thought to link pre-tRNA and pre-mRNA splicing events. TSEN2 (tRNA-splicing endonuclease subunit Sen2), also known as tRNA-intron endonuclease Sen2, is a 465 amino acid nuclear protein that constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex. There are three isoforms of TSEN2 that are produced as a result of alternative splicing events. Isoform 1 seems to carry the active site for 5’-splice site cleavage. Defects in the gene encoding TSEN2 are the cause of pontocerebellar hypoplasia type 2B, which is characterized by progressive microencephaly with epilepsy, extrapyramidal dyskinesia and chorea without spinal cord findings.

Function : Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.

Subunit : tRNA splicing endonuclease is a heterotetramer composed of isoform 1 of SEN2, SEN15, SEN34/LENG5 and SEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2. Isoform 2 belongs to a different complex that contains SEN54 but low level of SEN15 and SEN34/LENG5.

Subcellular Location : Nucleus

Tissue Specificity : Isoform 1 and isoform 2 are widely expressed at very low level.

Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE : Defects in TSEN2 are the cause of pontocerebellar hypoplasia type 2B (PCH2B) [MIM:612389]. Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem. PCH type 2 is characterized by progressive microcephaly from birth combined with extrapyramidal dyskinesia and chorea, epilepsy, and normal spinal cord findings.

Similarity : Belongs to the tRNA-intron endonuclease family.

Database links : UniProtKB/Swiss-Prot: Q8NCE0.2

实验流程：

正在热销的相关产品：

Anti-PD-1/FITC 荧光素标记程序性死亡1抗体IgGMulti-class antibodies规格： 0.2ml

Rabbit Anti-MK IgM/FITC 荧光素标记兔抗猴IgMMulti-class antibodies规格： 0.3ml

兔抗DLX4抗体 Anti-DLX4 0.2ml

Rabbit Anti-horse IgM/HRP 辣根过氧化物酶标记的兔抗马IgM 0.1ml

FBXL17 英文名称： FBXL17蛋白抗体 0.2ml

Rhesus antibody Rh phospho-TRAP220/MED1(Thr1457) 磷酸化甲状腺受体相关蛋白220抗体 规格 0.1ml

Rabbit Anti-MK IgM/FITC 荧光素标记兔抗猴IgMMulti-class antibodies规格： 0.3ml

Klf4 (Kruppel likefactor 4) 肠道内富含的Kruppel样因子抗原Multi-class antibodies规格： 0.5mg

Anti-alpha-L-arabinofuranosidase 果桃α-L-阿拉伯糖苷酶抗体Multi-class antibodies规格： 1ml

Rhesus antibody Rh Phospho-Caspase-9 (Ser196) 磷酸化半胱氨酸蛋白酶9抗体 规格 0.1ml

BSA封闭液 10ml Gibco原料,2%血清

VP2 英文名称： 重组猪细小病毒VP2蛋白抗体 0.2ml

DNA Polymerase delta, catalytic subunit 英文名称： DNA聚合酶δ催化亚单位/DNA pol δ cat抗体 0.2ml

Anti-alpha-L-arabinofuranosidase 果桃α-L-阿拉伯糖苷酶抗体Multi-class antibodies规格： 1ml

Anti- Alpha -HCG/Gold 胶体金离子α 亚基人绒毛膜激素单抗 IgGMulti-class antibodies规格： 0.2ml

ECE2(Endothelin Converting Enzyme 2) 内皮素转化酶2抗原Multi-class antibodies规格： 0.5mg

ADP核糖基化因子结合蛋白2抗体 Anti-ARFIP2/arfaptin 2 0.1ml

ZFAND5 英文名称： AN1型锌指蛋白5抗体 0.2ml

DPP6 英文名称： 二肽基肽酶6抗体 0.2ml

Rhesus antibody Rh phospho-eIF4EBP1/4EBP1(Ser64) 磷酸化4E结合蛋白1抗体 规格 0.1ml

ECE2(Endothelin Converting Enzyme 2) 内皮素转化酶2抗原Multi-class antibodies规格： 0.5mg

人β基己糖苷酶A(β-hexosaminidase A)ELISA 试剂盒 96T/48T 试剂盒 组装/原装

兔子蛋白聚糖4(PRG4)免疫试剂盒 Rabbit Proteoglycan 4,PRG4 ELISA kit

癌易感蛋白2(BRCA-2)ELISA试剂盒 ，英文名： BRCA-2 ELISA Kit

Porcineplateletactivatingfactor,PAFELISA试剂盒猪血小板活化因子(PAF)ELISA试剂盒规格：96T/48T

Humanangiostatin,ANGELISA试剂盒人抑素/稳定蛋白(ANG)ELISA试剂盒规格：96T/48T

HumanATP-bindingcassetteanspoerG2,ABCG2ELISAKit人腺苷三磷酸结合盒转运体G2(ABCG2)ELISA试剂盒规格：96T/48T

大鼠嗜酸粒细胞趋化蛋白Eotaxin 1(Eotaxin 1)ELISA试剂盒 ，英文名： Eotaxin 1 ELISA Kit

人膀胱抗原(BTA)ELISA检测试剂盒HumanBladdeumoraigen,BTAELISAKit 96T/48T

甲型H3N2 HA 免疫试剂盒 Influenza A H3N2 HA ELISA Kit

CLIAKitforPOMC(Humanpro-opiomelanocoin)ELISAKit人阿黑皮素原规格：48T/96T

石蜡切片组织P27蛋白表达荧光显微镜检测试剂盒10/20次

ELISAKitDNM2人发动蛋白规格：48T/96T

tRNA剪接内切酶2抗体费用 大鼠晚期糖基化终末产物(AGE)ELISA试剂盒 ，英文名： AGE ELISA Kit

人可溶性坏死因子相关凋亡诱导配体(sAIL)ELISA检测试剂盒Humansolubletumornecrosisfactor-relatedapoptosisinducingligand,sAILELISAKIT 96T/48T

仓鼠巨噬细胞迁移抑制因子(MIF)免疫试剂盒 Hamster macrophage migration inhibitory factor,MIF ELISA kit

CLIAKitforPYD(HumanPyridinolinecrosslinks)ELISAKit人胶原交联规格：48T/96T

石蜡切片脂肪酸费斯克勒(Fischler)直接染色试剂盒50次

ELISAKitBMPR-Ⅱ人骨成型蛋白受体Ⅱ规格：48T/96T

技术外包服务:

★tRNA剪接内切酶2抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。