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胸腺素β10抗体说明书 英文名称  Anti-T Beta 10

中文名称  胸腺素β10抗体说明书 

别    名 thymosin beta 10; MIG 12; MIG12; TB 10; TB10; Thyb 10; Thyb10; TMSB10; TYB10_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse

产品类型   一抗  

研究领域     免疫学 生长因子和激素

蛋白分子量  predicted molecular weight: 4.9kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human T Beta 10

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

胸腺素β10抗体说明书 产品应用   ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The beta thymosins are a family of related peptides, initially isolated from calf thymus but known to be present in a wide variety of mammalian and other vertebrate cells and tissues. Thymosin beta 4 was the first member of the family to be characterized. Although TMSB4 was initially proposed to be a thymic hormone acting at early stages of T cell maturation, the high concentration of the protein and its mRNA in a number of other tissues and cells, as well as the lack of an identifiable secretory signal sequence, suggested that it had a general function in many cell types. Thymosin beta 10 is closely related in sequence to TMSB4 and is also an actin sequestering protein.

Function : Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

Subcellular Location : Cytoplasm, cytoskeleton.

Similarity : Belongs to the thymosin beta family.

Database links : UniProtKB/Swiss-Prot: P63313.2

胸腺素β10同其他胸腺素一样也是多肽类激素，具有和，胸腺素可使由骨髓产生的干细胞转变为T淋巴细胞，因而可，对的影响甚微。

近年来研究认为：该蛋白于转移有关，胸腺素β10在转移潜能的增高伴有肌动蛋白多聚体的丢失和微丝结构的解聚,微丝骨架的这种变化与Tβ10的表达增高具有相关性。

实验流程：

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★胸腺素β10抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

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