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四分子交联体20抗体(四旋蛋白)规格
  • 品牌:上海莼试
  • 产地:进口、国产
  • 货号:CS11674
  • 发布日期: 2019-01-22
  • 更新日期: 2024-11-25
产品详请
产地 进口、国产
品牌 上海莼试
保存条件 Store at -20 °C
货号 CS11674
应用范围 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:50-200
CAS编号
抗体名 Anti-TSPAN20/UPIb
克隆性
靶点 详见说明书
适应物种 详见说明书
形态 详见说明书
宿主 详见说明书
亚型 IgG
标识物 详见说明书
浓度 1mg/1ml%
免疫原 KLH conjugated synthetic peptide derived from human TSPAN20/UPIb

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四分子交联体20抗体(四旋蛋白)规格 英文名称  Anti-TSPAN20/UPIb

中文名称  四分子交联体20抗体(四旋蛋白)规格 

     Tetraspanin-20; Tspan-20; TSPAN20; UP1b; UPIb; UPK1B; UPK1B_HUMAN; Uroplakin Ib; Uroplakin-1b.

产品属性:

      1mg/1ml

  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep

产品类型   一抗  

研究领域    细胞生物 信号转导 细胞分化

蛋白分子量  predicted molecular weight: 29kDa 

       Lyophilized or Liquid

  KLH conjugated synthetic peptide derived from human TSPAN20/UPIb

      IgG

纯化方法   affinity purified by Protein A

   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

四分子交联体20抗体(四旋蛋白)规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:50-200

(石蜡切片需做抗原修复) 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.

Function : Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.

Subunit : Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) (By similarity).

Subcellular Location : Membrane.

Tissue Specificity : Bladder epithelium.

Post-translational modifications : N-glycosylated with high-mannose oligosaccharides.

Similarity : Belongs to the tetraspanin (TM4SF) family.

Database links : UniProtKB/Swiss-Prot: O75841.5

实验流程:

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