TBC结构域TBCD4蛋白抗体费用 英文名称  Anti-TBCD4/TBC1D4

中文名称  TBC结构域TBCD4蛋白抗体费用 

别    名 Acrg embryonic lethality (mouse) minimal region ortholog; Acrg embryonic lethality minimal region ortholog; Acrg embryonic lethality mouse minimal region ortholog; Akt substrate of 160 kDa; AS 160; AS160; TBC (Tre 2 BUB2 CDC16) domain containing protein; TBC Tre 2 BUB2 CDC16 domain containing protein; TBC1 D4; TBC1 domain family member 4; Tbc1d4; TBCD4_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Pig, Cow, Sheep

产品类型   一抗  

研究领域    免疫学 信号转导 转录调节因子 G蛋白偶联受体

蛋白分子量  predicted molecular weight: 167kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TBCD4/TBC1D4

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

TBC结构域TBCD4蛋白抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Function : May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Subunit : Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

Tissue Specificity : Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.

Post-translational modifications : Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.

Similarity : Contains 2 PID domains.

Contains 1 Rab-GAP TBC domain.

Database links : UniProtKB/Swiss-Prot: O60343.2

实验流程：

全、新、优、品、好四大特点：

TBC结构域TBCD4蛋白抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

Anti-TP53/FITC 荧光素标记抗P53抗体IgGMulti-class antibodies规格： 0.2ml

PPAR-delta (peroxisome proliferator-activated receptor) D型-过氧化酶活化增生受体(多肽)Multi-class antibodies规格： 0.5mg

拓普西异构酶Ⅰ抗体 Anti-TPⅠ 0.2ml

MPP3 英文名称： 突触相关蛋白102抗体 0.2ml

ERC2 英文名称： CAST1蛋白抗体 0.2ml

Rhesus antibody Rh phospho-JAK2(Tyr221) 磷酸化蛋白酪氨酸激酶JAK-2抗体 规格 0.1ml

PPAR-delta (peroxisome proliferator-activated receptor) D型-过氧化酶活化增生受体(多肽)Multi-class antibodies规格： 0.5mg

Anti-Tbx21/T-bet/FITC 荧光素标记T细胞介导的转录调节因子Tbx21抗体IgGMulti-class antibodies规格： 0.2ml

M2-PK ( pyruvate Kinase M2 ) 酸激酶-M2(抗原)Multi-class antibodies规格： 0.5mg

造血细胞磷酸酶抗体 Anti-SHP-1 0.2ml

phospho-STAT3 (Tyr705) 英文名称： 磷酸化信号转导和转录激活因子3抗体 0.1ml

EYA2 英文名称： 眼睛发育缺失蛋白EYA2抗体 0.2ml

Rhesus antibody Rh phospho-M-CSF Receptor(Tyr708) 磷酸化巨噬细胞集落刺激因子受体抗体 规格 0.1ml

M2-PK ( pyruvate Kinase M2 ) 酸激酶-M2(抗原)Multi-class antibodies规格： 0.5mg

ENA human 人上皮细胞诱导中型粘细胞活化因子Multi-class antibodies规格： 48T

Anti-Phospho-Met (Tyr1349) 磷酸化肝细胞生长因子受体(原癌基因)抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh NPR2L/G21 protein G21蛋白质抗体 规格 0.2ml

IL-2 ELISA KIT 小鼠白介素2 96T

TSHB 英文名称： 小鼠抗促甲状腺素抗体 0.1ml

C6orf57 英文名称： 6号染色体开放阅读框57抗体 0.2ml

Anti-Phospho-Met (Tyr1349) 磷酸化肝细胞生长因子受体(原癌基因)抗体Multi-class antibodies规格： 0.1ml

VEGFA Protein Human 重组人 VEGF121b / VEGF-A 蛋白

HGC-27 人细胞(未分化)

CD80 Others Mouse 小鼠 CD80 / B7-1 人细胞裂解液 (阳性对照)

HuT 78人T淋巴细胞细胞 HuT 78 human T lymphocyte leukemia cell IMDM培养基+20%FBS

非洲绿猴肾细胞系/HCV-E1;Vero-HCV-E1

大鼠雪旺细胞(RSC)(5×105) 786-O [786-0], 人肾透明腺癌细胞 Human

CL-0386MPC-11(小鼠浆细胞瘤)5×106cells/瓶×2

EFNB1 Others Rat 大鼠 Ephrin-B1 / EFNB1 人细胞裂解液 (阳性对照)

小鼠气管平滑肌细胞完全培养基 100mL

EJ人细胞 Human bladder cancer cell line EJ 1640+10% FBS

IL36B Protein Mouse 重组小鼠 IL1F8 / IL36b 蛋白

NCI-H23(人非小细胞细胞) 5×106cells/瓶×2 THP-1(单核细胞)

TBC结构域TBCD4蛋白抗体费用 VEGFA Protein Human 重组人 VEGF121b / VEGF-A 蛋白

HGC-27 人细胞(未分化)

CD80 Others Mouse 小鼠 CD80 / B7-1 人细胞裂解液 (阳性对照)

HuT 78人T淋巴细胞细胞 HuT 78 human T lymphocyte leukemia cell IMDM培养基+20%FBS

非洲绿猴肾细胞系/HCV-E1;Vero-HCV-E1

大鼠雪旺细胞(RSC)(5×105) 786-O [786-0], 人肾透明腺癌细胞 Human

技术外包服务:

★TBC结构域TBCD4蛋白抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。