中文名称  硫氧还蛋白结合蛋白2抗体说明书 

英文名称  Anti-TXNIP

别    名 ;THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN.

产品属性：

硫氧还蛋白结合蛋白2抗体说明书 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Dog, Pig, Rabbit

产品类型   一抗  

研究领域     免疫学 转录调节因子

蛋白分子量  predicted molecular weight: 44kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human TXNIP

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

硫氧还蛋白结合蛋白2抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt).

Function : May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Subunit : Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains). Interacts with DDIT4.

Subcellular Location : Cytoplasm

Post-translational modifications : Ubiquitinated; undergoes polyubiquitination catalyzed by ITCH resulting in proteasomal degradation.

Similarity : Belongs to the arrestin family.

Database links : UniProtKB/Swiss-Prot: Q9H3M7.1

硫氧还蛋白结合蛋白-2 (TRX-binding protein-2，TBP-2)又称:维生素D3上调蛋白1(Vitamin D3 up-regulated protein 1，VDUP1)或称硫氧还蛋白相互作用蛋白(Thioredoxin-interacting protein，Txnip)。

TBP-2与硫氧还蛋白(thioredoxin，TRX)的活性部位结合，抑制其活性，除了参与多种氧化应激反应，还具有多种生物学功能。

有学者认为：TBP-2与密切相关，有些组织中，TBP-2表达降低或缺失。TBP-2表达增高时，细胞周期停滞，细胞繁殖受到抑制。目前已成为研究的重要靶点。

实验流程：

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硫氧还蛋白结合蛋白2抗体说明书 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

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优：产品质量好，投诉比较少。

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技术外包服务:

★硫氧还蛋白结合蛋白2抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

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