中文名称  感觉常染色体隐性遗传61抗体规格 

英文名称  Anti-Slc26a5

别    名 Prestin; Deafness neurosensory autosomal recessive 61; DFNB 61; DFNB61; MGC118886; MGC118887; MGC118888; MGC118889; PRES; Prestin (motor protein); Prestin; S26A5_HUMAN; SLC26A5; Solute carrier family 26 member 5 (prestin); Solute carrier family 26 member 5.

产品属性：

感觉常染色体隐性遗传61抗体规格 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域    细胞生物

蛋白分子量  predicted molecular weight: 81kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Slc26a5 C-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

感觉常染色体隐性遗传61抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 SLC26A5 (Solute carrier family 26, member 5) is specifically expressed in outer hair cells (OHCs) of the cochlea and is essential in auditory processing. It acts as a motor protein that converts auditory stimuli to length changes in outer hair cells. It is a bidirectional voltage-to-force converter which uses cytoplasmic anions as extrinsic voltage sensors. The anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. This translocation triggers conformational changes in the protein that alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). It acts as an incomplete transporter since it moves anions across the membrane, but does not allow the anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the anion-binding site. Mutations in SLC26A5 have been associated with non-syndromic hearing loss.

Function : Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site (By similarity).

Subcellular Location : Cell membrane; Multi-pass membrane protein (By similarity). Note=Lateral wall of outer hair cells (By similarity).

DISEASE : Deafness, autosomal recessive, 61 (DFNB61) [MIM:613865]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.

Contains 1 STAS domain.

Database links : UniProtKB/Swiss-Prot: P58743.1

外毛细胞具有在高频声作用下改变其长度的能力,这使哺乳动物听觉器官表现出高敏感性及频率的分辨能力。Prestin是近来被识别的一种外毛细胞马达蛋白,它在外毛细胞高表达,而内毛细胞不表达,定位在外毛细胞的外膜上,已发现Prestin与外毛细胞的电运动性有密切关系.

实验流程：

全、新、优、品、好四大特点：

感觉常染色体隐性遗传61抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★感觉常染色体隐性遗传61抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

Anti-TRAF1/Biotin 生物素化坏死因子受体相关因子1抗体Multi-class antibodies规格： 0.2ml

BRCA1(Breast cancer susceptbility gene 1)(human) 癌易感基因1抗原(人)Multi-class antibodies规格： 0.5mg

CD40结合蛋白/CD40受体相关因子1抗体 Anti-TRAF3/CD40bp 0.1ml

Sidekick 1 英文名称： 细胞粘附分子伴侣蛋白1抗体 0.2ml

ELAVL2 + ELAVL4 英文名称： ELAVL2+ELAVL4蛋白抗体 0.2ml

Rhesus antibody Rh phospho-IRS-2(Ser731) 磷酸化胰岛素受体底物2抗体 规格 0.1ml

BRCA1(Breast cancer susceptbility gene 1)(human) 癌易感基因1抗原(人)Multi-class antibodies规格： 0.5mg

Anti-TNF-alpha/ TNF- Alpha /FITC 荧光素标记鼠抗人坏死因子-α单克隆抗体 IgGMulti-class antibodies规格： 0.2ml

PDGF-A 血小板源性生长因子-1(抗原)Multi-class antibodies规格： 0.5mg

金属蛋白酶组织抑制因子-2抗体 Anti-TIMP-2 0.1ml

5HT5A receptor 英文名称： 5-羟色胺受体5A抗体 0.2ml

E2F3 英文名称： 转录因子E2F-3抗体 0.1ml

Rhesus antibody Rh phospho-Kidins220 (Ser918) 磷酸化220kDa蛋白激酶D相互作用蛋白抗体 规格 0.1ml

PDGF-A 血小板源性生长因子-1(抗原)Multi-class antibodies规格： 0.5mg

Pdx1(pancreatic and duodenal homeobox 1) 胰十二指肠同源异型盒基因抗原Multi-class antibodies规格： 0.5mg

Anti-ATP7A 铜转运蛋白质α链抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh phospho-AMPK beta 1(Ser108) 磷酸化腺苷单磷酸活化蛋白激酶β1抗体 规格 0.1ml

p21WAF1 浓缩液 0.1ml 进口分装

UCP-2 英文名称： 线粒体脱偶连蛋白2抗体 0.1ml

Dynamin 2 英文名称： 酶动力蛋白2抗体 0.1ml

Anti-ATP7A 铜转运蛋白质α链抗体Multi-class antibodies规格： 0.2ml

IL12A & IL12B Protein Human 重组人 IL-12 (IL12A & IL12B Heterodimer) 蛋白

小鼠软骨细胞完全培养基 100mL

ALPI Others Human 人 Alkaline Phosphatase / ALPI 人细胞裂解液 (阳性对照)

P3X63Ag8.653小鼠细胞 Mouse myeloma cell line P3X63Ag8.653 RPMI-1640(GIBCO)+10%FBS

CM-R092大鼠关节软骨细胞完全培养基100mL

USMC(大鼠平滑肌细胞) 5×106cells/瓶×2 HAVSMC, 人主动脉平滑肌细胞

CM-M008小鼠成纤维细胞完全培养基100mL

NPDC1 Others Human 人 NPDC-1 / NPDC1 人细胞裂解液 (阳性对照)

上皮细胞培养基EpiCM

SW 1271[SW-1271;SW1271]细胞，人 人肾透明细胞癌细胞,Caki-1细胞 人表皮黑色素细胞-HEM-a

猪肾传代细胞;IBRS-2

PDCD1 Others Human 人 PD1 / PDCD1 人细胞裂解液 (阳性对照)

感觉常染色体隐性遗传61抗体规格 IL12A & IL12B Protein Human 重组人 IL-12 (IL12A & IL12B Heterodimer) 蛋白

小鼠软骨细胞完全培养基 100mL

ALPI Others Human 人 Alkaline Phosphatase / ALPI 人细胞裂解液 (阳性对照)

P3X63Ag8.653小鼠细胞 Mouse myeloma cell line P3X63Ag8.653 RPMI-1640(GIBCO)+10%FBS

CM-R092大鼠关节软骨细胞完全培养基100mL

USMC(大鼠平滑肌细胞) 5×106cells/瓶×2 HAVSMC, 人主动脉平滑肌细胞