全、新、优、品、好四大特点：

信号转导分子SCDO3抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

信号转导分子SCDO3抗体规格 英文名称  Anti-SCDO3/Lunatic Fringe

中文名称  信号转导分子SCDO3抗体规格 

别    名 3-N-acetylglucosaminyltransferase lunatic fringe; Beta-1; Beta-13-N-acetylglucosaminyltransferase lunatic fringe; lfng; LFNG_HUMAN; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; SCDO3.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep

产品类型   一抗  

研究领域    细胞生物 发育生物学 神经生物学 信号转导

蛋白分子量  predicted molecular weight: 42kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SCDO3/Lunatic Fringe

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

信号转导分子SCDO3抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Three mammalian fringe family members, namely Manic Fringe, Radical Fringe and Lunatic Fringe, have been identified as proteins related to Drosophila fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Lunatic Fringe, also known as LFNG or SCDO3, is a 379 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Functioning as a glycosyltransferase, Lunatic Fringe acts a critical mediator of somite patterning and segmentation and plays a fundamental role in initiating the elongation of O-linked fucose residues that are attached to Notch molecules. Defects in the gene encoding Lunatic Fringe are the cause of autosomal recessive spondylocostal dysostosis 3 (SCDO3), a disorder that arises during embryonic development and is characterized by rib anomalies and multiple vertebrate segmentation. Three isoforms of Lunatic Fringe are expressed due to alternative splicing events.

Function : Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.

Subcellular Location : Golgi apparatus membrane; Single-pass type II membrane protein

Post-translational modifications : A soluble form may be derived from the membrane form by proteolytic processing.

DISEASE : Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

Similarity : Belongs to the glycosyltransferase 31 family.

Database links : UniProtKB/Swiss-Prot: Q8NES3.2

实验流程：

正在热销的相关产品：

Anti-Tau protein/FITC 荧光素标记微管相关蛋白抗体IgGMulti-class antibodies规格： 0.2ml

IRS-2 受体底物-2(抗原)Multi-class antibodies规格： 0.5mg

干细胞生长因子抗体 Anti-SCF 0.2ml

semaphorin 3F 英文名称： 臂板蛋白3F抗体 0.1ml

EED 英文名称： 胚胎外胚层发育蛋白EED抗体 0.2ml

Rhesus antibody Rh phospho-MEF2D(Ser444) 磷酸化肌细胞特异性增强因子2D抗体 规格 0.1ml

IRS-2 受体底物-2(抗原)Multi-class antibodies规格： 0.5mg

Anti-phospho-c-Jun/AP-1(pThr91/pThr93)/FITC 荧光素标记抗磷酸化原癌基因c-Jun抗体IgGMulti-class antibodies规格： 0.2ml

Rabbit Anti-chicken IgG 兔抗鸡IgG (亲和层析纯化)Multi-class antibodies规格： 1mg

生长激素释放激素因抗体 Anti-GHRF/GHRH 0.1ml

Goat Anti-Chicken IgG/Alexa Fluor 647 Alexa Fluor 647标记的羊抗鸡IgG 0.1ml

FADS1 英文名称： 脂肪酸去饱和酶1抗体 0.2ml

Rhesus antibody Rh phospho-SLAMF1(Tyr281) 磷酸化信号淋巴细胞活化分子CD150抗体 规格 0.1ml

Rabbit Anti-chicken IgG 兔抗鸡IgG (亲和层析纯化)Multi-class antibodies规格： 1mg

P2P-R/RBBP6(proliferation potential protein related) 增殖潜能相关蛋白抗原Multi-class antibodies规格： 0.5mg

Anti-Artemin Artemin抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh phospho-Arhgef2(Ser810) 磷酸化Rho鸟苷酸交换因子2抗体 规格 0.1ml

TIMP-2 浓缩液 0.1ml 进口分装

Utrophin 英文名称： 肌蛋白相关蛋白1抗体 0.2ml

DHRS7C 英文名称： 短链脱氢酶/还原酶家族7C抗体 0.2ml

Anti-Artemin Artemin抗体Multi-class antibodies规格： 0.2ml

IL1B Protein Mouse 重组小鼠 IL-1 beta / IL1B 蛋白

小鼠肺动脉成纤维细胞完全培养基 100mL

CNDP1 Others Mouse 小鼠 CNDP1 人细胞裂解液 (阳性对照)

Psi2 DAP小鼠胚胎成纤维细胞 Psi2 DAP mouse embryo fibroblasts DMEM培养基+10%FBS

CL-0329Chang liver (CCL13) (人张氏肝细胞)5×106cells/瓶×2

NCI-H596(人肺腺鳞癌细胞) 5×106cells/瓶×2 A10(大鼠主动脉平滑肌细胞)

CM-R033大鼠肝实质细胞完全培养基100mL

SHH Others Mouse 小鼠 SHH / Sonic hedgehog 人细胞裂解液 (阳性对照)

人卵巢成纤维细胞HOF

JEG-3/VP16-IL-2细胞，白介素-2转染耐VP16绒癌细胞 兔角膜后基质层成纤维细胞,RCBBF细胞 人羊膜间充质基质细胞HAMSC

INS-1(大鼠胰岛细胞瘤细胞) 5×106cells/瓶×2

A172(人脑细胞) 5×106cells/瓶×2 CM-H107人软骨细胞完全培养基100mL 人胚肾二倍体细胞;CCC-HEK-1

信号转导分子SCDO3抗体规格 IL1B Protein Mouse 重组小鼠 IL-1 beta / IL1B 蛋白

小鼠肺动脉成纤维细胞完全培养基 100mL

CNDP1 Others Mouse 小鼠 CNDP1 人细胞裂解液 (阳性对照)

Psi2 DAP小鼠胚胎成纤维细胞 Psi2 DAP mouse embryo fibroblasts DMEM培养基+10%FBS

CL-0329Chang liver (CCL13) (人张氏肝细胞)5×106cells/瓶×2

NCI-H596(人肺腺鳞癌细胞) 5×106cells/瓶×2 A10(大鼠主动脉平滑肌细胞)

技术外包服务:

★信号转导分子SCDO3抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。