中文名称  非红细胞血影脑蛋白β2/spectrin β III抗体说明书 

英文名称  Anti-SPTBN2/Beta III spectrin

别    名 Beta III spectrin; Beta-III spectrin; SCA 5; SCA5; Spectrin beta chain brain 2; Spectrin beta non erythrocytic 2; Spectrin non erythroid beta chain 2; Spinocerebellar ataxia 5; SPTBN 2; Spectrin beta chain, non-erythrocytic 2; Beta-III spectrin; Spinocerebellar ataxia 5 protein; SPTN2_HUMAN.

产品属性：

非红细胞血影脑蛋白β2/spectrin β III抗体说明书 浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域    神经生物学 信号转导 细胞骨架 细胞外基质

蛋白分子量  predicted molecular weight: 35kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human Beta III spectrin (121-220aa)

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

非红细胞血影脑蛋白β2/spectrin β III抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin Alpha and spectrin Beta are present in erythrocytes, whereas spectrin Alpha II (also designated fodrin Alpha) and spectrin Beta I (also designated fodrin Beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin Beta III is highly homologous to both spectrin Beta I and spectrin Beta II. Western blot analysis shows that spectrin Beta III migrates at a higher molecular mass than predicted in the kidney. Spectrin Beta III is highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta. Specifically, spectrin Beta III constitutes a major component of the Golgi and vesicular membrane skeletons.

Function : Probably plays an important role in neuronal membrane skeleton.

Subcellular Location : Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.

Tissue Specificity : Highly expressed in brain, kidney, pancreas, and liver, and at lower levels in lung and placenta.

DISEASE : Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5) [MIM:600224]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.

Similarity : Belongs to the spectrin family.

Contains 2 CH (calponin-homology) domains.

Contains 1 PH domain.

Contains 17 spectrin repeats.

Database links : UniProtKB/Swiss-Prot: O15020.3

实验流程：

全、新、优、品、好四大特点：

非红细胞血影脑蛋白β2/spectrin β III抗体说明书 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

技术外包服务:

★非红细胞血影脑蛋白β2/spectrin β III抗体说明书 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

正在热销的相关产品：

Anti-SPY /FITC 荧光素标记抗spindly抗体IgGMulti-class antibodies规格： 0.2ml

Aggrecan 软骨蛋白聚糖/可聚蛋白多糖抗原Multi-class antibodies规格： 0.5mg

磷脂酸磷酸酶2C抗体 Anti-PAP2c 0.1ml

SIRT4 英文名称： 沉默调节相关蛋白4抗体 0.2ml

ECP 英文名称： 嗜酸性粒细胞阳离子蛋白抗体 0.1ml

Rhesus antibody Rh phospho-NFKB p65(Thr435) 磷酸化细胞核因子抗体 规格 0.1ml

Aggrecan 软骨蛋白聚糖/可聚蛋白多糖抗原Multi-class antibodies规格： 0.5mg

Anti-phospho-ERK1(pThr202/pTyr204)/FITC 荧光素标记抗磷酸化原活化蛋白激酶1抗体IgGMulti-class antibodies规格： 0.2ml

Rabbit Anti-FITC/Gold 金标记兔抗荧光素 (10nm/15nm)Multi-class antibodies规格： 2ml

纤维母细胞生长因子受体1抗体 Anti-FGFR1 0.1ml

Goat Anti-Mouse IgG/PE PE标记的羊抗小鼠IgG 0.1ml

FOXF2 英文名称： 叉头蛋白F2抗体 0.2ml

Rhesus antibody Rh phospho-Stathmin 1 (Ser63) 磷酸化原癌基因蛋白18抗体 规格 0.1ml

Rabbit Anti-FITC/Gold 金标记兔抗荧光素 (10nm/15nm)Multi-class antibodies规格： 2ml

ASK1/MAPKKK5 细胞凋亡信号调节激酶1/原活化蛋白激酶激酶激酶5抗原Multi-class antibodies规格： 0.5mg

Anti-AMPK alpha 1 腺苷单磷酸活化蛋白激酶α1抗体Multi-class antibodies规格： 0.1ml

Rhesus antibody Rh Phospho-BRCA1(Ser1189) 磷酸化癌易感基因1抗体 规格 0.1ml

Tris-EDTA缓冲液(50X) 50ml pH 9.0,高背景着色

VASP 英文名称： 扩张刺激磷蛋白抗体 0.1ml

Defensin alpha 6 英文名称： 防御素α6抗体 0.2ml

Anti-AMPK alpha 1 腺苷单磷酸活化蛋白激酶α1抗体Multi-class antibodies规格： 0.1ml

IL36G Protein Mouse 重组小鼠 IL36G / IL1F9 蛋白 (His 标签)

大鼠晶状体上皮细胞完全培养基 100mL

CN3 Others Mouse 小鼠 Coactin 3 / CN3 人细胞裂解液 (阳性对照)

EB (NBL-4)牛胚气管细胞 EB (NBL-4) of bovine embryo acheal cells MEM培养基(GIBCO)+10%FBS

CL-0459U14(小鼠子细胞)5×106cells/瓶×2

NCI-H446(人小细胞细胞) 5×106cells/瓶×2 HeLa(细胞)

CM-R069大鼠肾成纤维细胞完全培养基100mL

CLEC7A Others Human 人 CLEC7A / Dectin-1 / CLECSF12 人细胞裂解液 (阳性对照)

大鼠肝星形细胞RHSteC

NCI-H596[H596]细胞，人细胞 人细胞,SK-RC-42细胞 人肝星形细胞HHSteC

小香猪皮肤细胞;SSC-S2

NCR3 Others Human 人 NKp30 人细胞裂解液 (阳性对照)

非红细胞血影脑蛋白β2/spectrin β III抗体说明书 IL36G Protein Mouse 重组小鼠 IL36G / IL1F9 蛋白 (His 标签)

大鼠晶状体上皮细胞完全培养基 100mL

CN3 Others Mouse 小鼠 Coactin 3 / CN3 人细胞裂解液 (阳性对照)

EB (NBL-4)牛胚气管细胞 EB (NBL-4) of bovine embryo acheal cells MEM培养基(GIBCO)+10%FBS

CL-0459U14(小鼠子细胞)5×106cells/瓶×2

NCI-H446(人小细胞细胞) 5×106cells/瓶×2 HeLa(细胞)