SPG48蛋白抗体规格 英文名称  Anti-SPG48

中文名称  SPG48蛋白抗体规格 

别    名 Hypothetical protein LOC9907; KIAA0415; Uncharacterized protein KIAA0415; AP5Z1_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human

产品类型   一抗  

研究领域    细胞生物 神经生物学 表观遗传学

蛋白分子量  predicted molecular weight: 89kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human SPG48 (288-370aa)

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

SPG48蛋白抗体规格 产品应用   WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. KIAA0415 is a 807 amino acid protein that exists as three alternatively spliced isoforms. The KIAA0415 gene product has been provisionally designated KIAA0415 pending further characterization.

Function : The function of SPG48 remains unknown. There are 3 named isoforms produced by alternative splicing.

Subunit : Probably part of the adapter protein complex 5 (AP-5) atetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts withZFYVE26 and SPG11.

Subcellular Location : Cytoplasm. Nucleus. Note=By SDS-PAGE, 2isoforms have been observed, the shorter seems to be predominantlynuclear and the longer is mostly cytoplasmic (PubMed:20613862).

DISEASE : Defects in AP5Z1 are the cause of spastic paraplegiaautosomal recessive type 48 (SPG48) [MIM:613647]. A form of spasticparaplegia, a neurodegenerative disorder characterized by a slow,gradual, progressive weakness and spasticity of the lower limbs.Rate of progression and the severity of symptoms are quitevariable. Initial symptoms may include difficulty with balance,weakness and stiffness in the legs, muscle spasms, and dragging thetoes when walking. In some forms of the disorder, bladder symptoms(such as incontinence) may appear, or the weakness and stiffnessmay spread to other parts of the body.

Database links : UniProtKB/Swiss-Prot: O43299.2

实验流程：

全、新、优、品、好四大特点：

SPG48蛋白抗体规格 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

Goat Anti-human Fibrinogen/HRP 辣根过氧化物酶标记羊抗人纤维蛋白原Multi-class antibodies规格： 0.1ml

CCL1/TCA3/I-309 嗜酸粒细胞趋化蛋白CCL1抗原Multi-class antibodies规格： 0.5mg

酶1抗体 Anti-CA I 0.1ml

SEMA4G 英文名称： 跨膜蛋白SEMA4G抗体 0.2ml

ECM1 英文名称： 细胞外基质蛋白1抗体 0.1ml

Rhesus antibody Rh Phospho-HSL (Ser660) 磷酸化荷尔蒙敏感脂肪酶抗体 规格 0.1ml

CCL1/TCA3/I-309 嗜酸粒细胞趋化蛋白CCL1抗原Multi-class antibodies规格： 0.5mg

Anti-phospho-MK1/MAPKK1(pSer298)/FITC 荧光素标记抗磷酸化原活化蛋白激酶激酶1抗体IgGMulti-class antibodies规格： 0.2ml

Rabbit Anti-Goat IgG 兔抗羊IgG (亲和层析纯化)Multi-class antibodies规格： 1mg

下游转录因子Gli1蛋白抗体 Anti-GLI1 0.2ml

Rabbit Anti-Bov IgG/PE-Cy5.5 PE-Cy5.5标记的兔抗IgG 0.1ml

FAM13B1 英文名称： FAM13B1蛋白抗体 0.2ml

Rhesus antibody Rh Phospho-SHP2/SHIP2(Tyr81) 磷酸化蛋白酪氨酸磷酸酶2抗体 规格 0.1ml

Rabbit Anti-Goat IgG 兔抗羊IgG (亲和层析纯化)Multi-class antibodies规格： 1mg

Neurocan 神经粘蛋白抗原Multi-class antibodies规格： 0.5mg

Anti-ATH III 凝血酶Ⅲ抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh phospho-AXL (Tyr698+Tyr702+Tyr703) 磷酸化粘附相关激酶抗体 规格 0.1ml

山羊抗大鼠 IgG(H+L)/Biotin 0.1ml 美国Jackson公司分装

VAT1 英文名称： 嗜铬颗粒胺转运蛋白VAT1抗体 0.1ml

DAP12 英文名称： 自然杀伤激活受体相关蛋白DAP12抗体 0.1ml

Anti-ATH III 凝血酶Ⅲ抗体Multi-class antibodies规格： 0.2ml

IL1RL1 Protein Mouse 重组小鼠 IL1RL1 / ST2 蛋白 (His 标签)

大鼠视网膜muller细胞 100mL

TNFRSF12A Others Human 人 TNFRSF12A / FN14 / TWEAKR 人细胞裂解液 (阳性对照)

F81猫肾细胞 F81 feline kidney cells RPMI-1640(GIBCO)+10%FBS

人骨髓间充质干细胞(hMSCs)

NCI-H295R(人肾上腺皮质腺癌细胞) 5×106cells/瓶×2 Neuro-2A(脑神经瘤细胞)

CM-R073大鼠心肌细胞完全培养基100mL

FGFR1 Others Cynomolgus 食蟹猴 FGFR1 人细胞裂解液 (阳性对照)

小鼠脑膜细胞MMenC

JAR细胞，人胎盘绒毛癌细胞 小鼠成纤维细胞,C3H 10T1/2 2A6细胞 人纤维环细胞HAFC

Hs68(人男性正常细胞) 5×106cells/瓶×2

4T1(小鼠癌细胞) 5×106cells/瓶×2 CM-H067人肾系膜细胞完全培养基100mL 人心肝成纤维细胞RNAHCF miRNA5 μg

SPG48蛋白抗体规格 IL1RL1 Protein Mouse 重组小鼠 IL1RL1 / ST2 蛋白 (His 标签)

大鼠视网膜muller细胞 100mL

TNFRSF12A Others Human 人 TNFRSF12A / FN14 / TWEAKR 人细胞裂解液 (阳性对照)

F81猫肾细胞 F81 feline kidney cells RPMI-1640(GIBCO)+10%FBS

人骨髓间充质干细胞(hMSCs)

NCI-H295R(人肾上腺皮质腺癌细胞) 5×106cells/瓶×2 Neuro-2A(脑神经瘤细胞)

技术外包服务:

★SPG48蛋白抗体规格 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。