磷酸化G蛋白信号转导调节因子19抗体说明书 英文名称  Anti-phospho-RGS19(Tyr143)

中文名称  磷酸化G蛋白信号转导调节因子19抗体说明书 

别    名 RGS19(phospho Y143); RGS19(phospho Ser143); G alpha interacting protein; GAIP; GNAI3IP; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein; Regulator of G protein signalling 19; RGSGAIP; RGS19_HUMAN; Regulator of G-protein signaling 19; RGS19; G-alpha-interacting protein.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, chk, shp, dog, hrs, cow

产品类型   一抗 磷酸化抗体  

研究领域     免疫学 信号转导 细胞凋亡 转录调节因子

蛋白分子量  predicted molecular weight: 25kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated Synthesised phosphopeptide derived from human RGS19 around the phosphorylation site of Tyr143 [LI(p-Y)ED]

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

磷酸化G蛋白信号转导调节因子19抗体说明书 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase activating protein that functions to down regulate Galpha i/Galpha q linked signaling.

Function : Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Subunit : Interacts with GIPC PDZ domain.

Subcellular Location : Membrane; Lipid-anchor.

Tissue Specificity : Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.

Post-translational modifications : Fatty acylated. Heavily palmitoylated in the cysteine string motif.

Phosphorylated, mainly on serine residues.

Similarity : Contains 1 RGS domain.

Database links : UniProtKB/Swiss-Prot: P49795.1

实验流程：

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