技术外包服务:

★增殖潜能相关蛋白抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

实验流程：

增殖潜能相关蛋白抗体费用 英文名称  Anti-RBBP6/P2P-R

中文名称  增殖潜能相关蛋白抗体费用 

别    名 Retinoblastoma-binding protein 6; proliferation potential protein related; p53-associated cellular protein of testis; Proliferation potential-related protein; Retinoblastoma-binding Q protein 1; Protein RBQ-1; My038; PACT; Protein P2P-R; RBBP6_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域     细胞生物 发育生物学 信号转导 细胞周期蛋白

蛋白分子量  predicted molecular weight: 201kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from humna P2PR N-terminus

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

增殖潜能相关蛋白抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 P2P-R/RBBP6 (Retinoblastoma- binding protein 6; proliferation potential protein related; p53-associated cellular protein of testis; Proliferation potential-related protein; Retinoblastoma-binding Q protein 1; Protein RBQ-1; My038; PACT; Protein P2P-R;) interacts with p53/TP53 and RB1 (By similarity). [SUBCELLULAR LOCATION] Nucleus, nucleolus. [TISSUE SPECIFICITY] Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Function : E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth.

Subunit : Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6.

Subcellular Location : Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, centrosome. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome.

Tissue Specificity : Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.

Post-translational modifications : Phosphorylated by NEK6.

Similarity : Contains 1 CCHC-type zinc finger.

Contains 1 DWNN domain.

Contains 1 RING-type zinc finger.

Database links : UniProtKB/Swiss-Prot: Q7Z6E9.1

信号传导（Signaling Intermediates）

P2P-P又称PACT即P53相关细胞蛋白（P53 associated cellular protein-testes derived）， P2P-P蛋白是p53的负调控因子，而且在细胞生长和胚胎发育，细胞分化、前体mRNA剪接、周期阻滞、凋亡过程中起到了重要作用。

全、新、优、品、好四大特点：

增殖潜能相关蛋白抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

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