技术外包服务:

★信号转导和转录激活因子4抗体费用 分子生物学：质粒抽提、PCR、Q-PCR、RT-PCR、分子生物学：基因合成、引物合成、基因测序、载体构建等

★蛋白工程：原核、哺乳动物蛋白表达系统等

★病毒包装：腺病毒、慢病毒等

★抗体工程：磁珠分选、病理染色、WB、ELISA、IP、IF、IHC、FACS、Confocal等等

★细胞工程：细胞表型分析(凋亡、增殖、周期、迁移、侵袭、修复、克隆形成)、细胞培养、细胞膜制备、稳定细胞株构建、细胞RNAi技术等等。

实验流程：

信号转导和转录激活因子4抗体费用 英文名称  Anti-STAT4

中文名称  信号转导和转录激活因子4抗体费用 

别    名 signal transducers and activators of transduction 4; CIS4; HSPC060; SOCS4; SOCS6; SSI4; STAI4; STAT 4; STAT4; STATI4; Suppressor of cytokine signaling 6; STAT4_HUMAN.

产品属性：

浓    度  1mg/1ml

规 格  0.1ml/100μg 0.2ml/200μg

抗体来源  Rabbit

克隆类型   polyclonal

交叉反应   Human, Mouse, Rat

产品类型   一抗  

研究领域     细胞生物 发育生物学 信号转导 细胞凋亡 转录调节因子

蛋白分子量  predicted molecular weight: 85kDa 

性    状   Lyophilized or Liquid

免 疫 原  KLH conjugated synthetic peptide derived from human STAT4

亚    型  IgG

纯化方法   affinity purified by Protein A

储 存 液   0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

信号转导和转录激活因子4抗体费用 产品应用   WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品介绍 The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011].

Function : Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

Subunit : Forms a homodimer or a heterodimer with a related family member. Interacts with ARL2BP (By similarity). The SH2 domain interacts, in vitro, with IL12RB2 via a short cytoplasmic domain.

Subcellular Location : Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Post-translational modifications : Tyrosine phosphorylated. Serine phosphorylation is also required for maximal transcriptional activity.

DISEASE : Genetic variations in STAT4 are associated with susceptibility to systemic lupus erythematosus type 11 (SLEB11) [MIM:612253]. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

Genetic variations in STAT4 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Similarity : Belongs to the transcription factor STAT family.

Contains 1 SH2 domain.

Database links : UniProtKB/Swiss-Prot: Q14765.1

全、新、优、品、好四大特点：

信号转导和转录激活因子4抗体费用 全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。

新：产品更新速度较快，基本上每周都有新产品出现。

优：产品质量好，投诉比较少。

好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。

正在热销的相关产品：

HSTF2/HSF2 peptide 热休克转录因子2抗原Multi-class antibodies规格： 0.5mg

Anti-ABCG4 ABC膜转运蛋白抗体Multi-class antibodies规格： 0.2ml

Rhesus antibody Rh Phospho-CHK2 (ser19) 磷酸化细胞周期检测点激酶2抗体 规格 0.1ml

兔抗Avidin(卵清亲合素)血清 0.5ml 国产

WNK1 英文名称： 赖酸缺陷型蛋白激酶1抗体 0.2ml

Doublecortin 英文名称： 双皮质素抗体 0.1ml

Anti-ABCG4 ABC膜转运蛋白抗体Multi-class antibodies规格： 0.2ml

Anti-PADI4/PAD4 /FITC 荧光素标记相关基因抗体IgGMulti-class antibodies规格： 0.2ml

Rabbit Anti-rat IgM/Biotin 生物素化兔抗大鼠IgMMulti-class antibodies规格： 0.1ml

周期素C抗体 Anti-Cyclin C 0.1ml

Rabbit Anti-Monkey IgM/PE-CY5 PE-CY5标记的兔抗猴IgM 0.1ml

FBXO31 英文名称： F-box蛋白家族FBXO31抗体 0.2ml

Rhesus antibody Rh phospho-VAV3(Tyr173) 磷酸化鸟嘌呤核苷酸交换因子VAV3抗体 规格 0.1ml

Rabbit Anti-rat IgM/Biotin 生物素化兔抗大鼠IgMMulti-class antibodies规格： 0.1ml

SYK 英文名称： 非受体型酪酸蛋白激酶抗体 0.1ml

EphA3 英文名称： 酪酸蛋白激酶受体A3抗体 0.1ml

细胞外基质金属蛋白酶诱导因子抗体 Anti-CD147/EMMPRIN 0.1ml

Anti-CD4/Biotin 生物素化CD4抗体IgGMulti-class antibodies规格： 0.2ml

Rhesus antibody Rh phospho-HDAC1(Ser423) 磷酸化组蛋白去乙酰化酶1抗体 规格 0.1ml

Pentapeptide-3/Leuphasyl 五胜肽Multi-class antibodies规格： 1g

人间充质干细胞-脐带

OS-RC-2 人细胞

LBP Others Human 人 LBP / Lipopolysaccharide Binding 人细胞裂解液 (阳性对照)

MEF, 小鼠胚胎成纤维细胞

人脐动脉平滑肌细胞RNAHUASMC miRNA5 μg

人胚胎，皮肤，肌肉;M-20 人外周血白细胞完全培养基 100mL

CL-0210SiHa(人子宫颈鳞癌细胞)5×106cells/瓶×2

REG4 Others Human 人 REG4 / RELP / GISP CHO细胞裂解液 (阳性对照)

人真皮平滑肌细胞cDNAHDLEC cDNA

猪肾细胞;PK-15 子宫内膜腺癌细胞，HEC-1-B细胞 Fc细胞，615小鼠前瘤株

人胚肾细胞;293FT

HA Others H1N1 甲型 H1N1 (A/WSN/1933) 血凝素 (Hemagglutinin / HA) 人细胞裂解液 (阳性对照)

信号转导和转录激活因子4抗体费用 人间充质干细胞-脐带

OS-RC-2 人细胞

LBP Others Human 人 LBP / Lipopolysaccharide Binding 人细胞裂解液 (阳性对照)

MEF, 小鼠胚胎成纤维细胞

人脐动脉平滑肌细胞RNAHUASMC miRNA5 μg

人胚胎，皮肤，肌肉;M-20 人外周血白细胞完全培养基 100mL